8. Farah Lubin, PhD on epigenetics and the brain

11/12/24 • 65 min

In this episode, I sit down with Dr. Farah Lubin, a neuroscientist from the University of Alabama at Birmingham, to explore the fascinating world of epigenetics in the brain. Dr. Lubin shares her groundbreaking research on how gene expression can influence memory formation and neurological disorders like epilepsy. We also discuss how understanding these mechanisms could lead to novel therapies, along with the transformative power of epigenetics in brain science. Follow along as Dr. Lubin walks us through her unique career journey and sheds light on the evolving field of neuroepigenetics.

Timestamps:

(00:00) - Introduction to Dr. Farah Lubin and her research on epigenetics
(06:00) - Epigenetic mechanisms: DNA methylation and histone modifications
(09:00) - Epigenetics and brain plasticity in memory and learning
(12:00) - The role of DNA methylation in gene expression and memory
(18:00) - Epigenetics and the consolidation of long-term fear memories
(25:00) - How brain-derived neurotrophic factor (BDNF) is influenced by epigenetics
(30:00) - The role of epigenetics in epilepsy development and resilience
(35:00) - Methionine supplementation and its potential impact on memory
(40:00) - The importance of environmental influences on the epigenome
(46:00) - Future directions in epigenetics: new sequencing technologies
(52:00) - Funding challenges in neuroscience research and the value of basic science
(56:00) - Advice for students interested in neuroscience and epigenetics

Timestamps:

Previous Episode

7. Gill Livingston, MD on preventing dementia

In this episode, I chat with Dr. Gill Livingston about her groundbreaking research on dementia. Dr. Livingston has played an important role in uncovering the lifestyle, environmental, and genetic factors that contribute to our risk of developing dementia. Follow her on X @Gill_Livingston for more insights.

Timestamps:

(00:00) - Introduction to Dr. Gill Livingston and Her Research on Dementia
(00:30) - Dr. Livingston's Career Path and Inspiration for Dementia Research
(06:35) - The Lancet Commission on Dementia Prevention and Key Findings
(09:53) - Understanding Dementia’s Preventability and Main Risk Factors
(12:22) - Hearing Loss and Other Key Dementia Risk Factors
(22:45) - Blood Pressure, Air Pollution, and Dementia Risk
(29:44) - Amyloid Beta and Tau’s Role in Alzheimer’s Disease
(36:59) - Cognitive Reserve and the Impact of Education on Dementia Risk
(41:12) - Genetics in Dementia: APOE4 and Other Risk Genes
(46:24) - The Immune System’s Role in Alzheimer’s and Potential Treatments
(50:12) - Policy Implications for Dementia Prevention
(01:04:01) - Dr. Livingston’s Ongoing Research

Next Episode

9. Glenn Fox, PhD on the science of gratitude

In this episode of Sentience, neuroscientist Dr. Glenn Fox takes us on a fascinating journey through the science of gratitude. From his pioneering brain-imaging studies on Holocaust survivor testimonies to developing practical frameworks for entrepreneurs, Glenn reveals how gratitude impacts our brains, emotional health, and resilience. We discuss why gratitude is uniquely powerful, especially during difficult times, and how understanding its neural and psychological foundations can transform our personal and professional lives. Tune in for insights into cultivating genuine gratitude—and discover why it's far more profound than simply "feeling happy."

You can find Dr. Foxx on Instagram @profGlennFox.

Timestamps:

(00:00) - Introduction to Dr. Glenn Fox and the neuroscience of gratitude

(01:01) - Glenn’s personal journey into studying gratitude

(07:43) - Gratitude research: clinical vs. positive psychology perspectives

(11:58) - Defining gratitude using the "gift space" model

(19:18) - Applying gratitude beyond gift-giving scenarios

(32:44) - Differentiating gratitude from other positive emotions like happiness

(39:44) - Neuroscience of gratitude: lessons from Holocaust survivor testimonies

(54:09) - The role of the mu-opioid system in gratitude and pain relief

(1:02:29) - Gratitude’s role in entrepreneurship and managing stress

(1:12:23) - Personal reflections on practicing gratitude and creativity