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Regenerative Medicine and Gene Therapy

Regenerative Medicine and Gene Therapy

ICGEB

Topics looking at the technique for correcting defective genes responsible for disease development.
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Top 10 Regenerative Medicine and Gene Therapy Episodes

Goodpods has curated a list of the 10 best Regenerative Medicine and Gene Therapy episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to Regenerative Medicine and Gene Therapy for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite Regenerative Medicine and Gene Therapy episode by adding your comments to the episode page.

Katja Schenke-Layland, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Cell and Tissue Engineering, Cardiovascular Tissue Engineering, Stuttgart - GERMANY speaks on "Extracellular matrix – A natural biomaterial for tissue engineering applications". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - A. Barzel - Therapeutic levels of in vivo gene targeting without nucleases
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02/17/16 • 38 min

Adi BARZEL, Founder and Chief Scientific Officer of LogicBio Therapeutics Inc. Tel Aviv - ISRAEL speaks on "Therapeutic levels of in vivo gene targeting without nucleases". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - M. Rigoni - Neurotoxins-induced degeneration and regeneration of motor axon terminals
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03/31/15 • 31 min

Michela Rigoni, Dept. of Biomedical Sciences, University of Padua, Padua - ITALY speaks on "Neurotoxins-induced degeneration and regeneration of motor axon terminals". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - L. Carrier - RNA-based therapy for cardiac genetic disease
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10/01/13 • 33 min

Lucie Carrier, Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY speaks on "RNA-based therapy for cardiac genetic disease". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - F. Mavilio - Integrated approaches to gene therapy of genetic diseases
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07/06/13 • 50 min

Fulvio Mavilio, Genethon, Paris - FRANCE "Integrated approaches to gene therapy of genetic diseases". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - T. Cathomen - Zinc positive: designer nucleases in gene therapy
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07/09/10 • 42 min

Toni Cathomen, Hannover Medical School, Experimental Hematology, Hannover, GERMANY speaks on "Zinc positive: designer nucleases in gene therapy". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - L. Hein - Dynamics of the epigenome in cardiac myocyte development and disease
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06/04/18 • 49 min

Lutz Hein, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany speaks on "Dynamics of the epigenome in cardiac myocyte development and disease". This movie has been recorded at ICGEB Trieste.
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Eduard Ayuso, INSERM 1089, University of Nantes, Nantes, France speaks on "Unraveling mechanisms and biology of recombinant AAV vectors
produced in insect cells". Recombinant adeno-associated vectors (rAAV) are viral vectors of choice for gene therapy of many inherited diseases. Medicinal products based on rAAV are predominantly manufactured by transient transfection of mammalian cells or baculovirus expressing vectors (BEV) infection of insect cells, being the latter method more suitable for large-scale production. Although AAVs are mammalian viruses they can be assembled in insect cells, but the biology of the system has been poorly investigated. Here, we have studied the role of the assembly-activating protein (AAP) in insect cells and we found that this protein is expressed in a similar manner as in mammalian cells. By knocking down the AAP, it was confirmed that AAP is required for the assembly of AAV2 particles in insect cells. Next, we aimed to identify and characterize DNA species encapsidated in rAAV stocks produced in insect cells. To this end, we developed a single-strand virus sequencing protocol based on Illumina high-throughput sequencing technology (HTS). Preliminary data obtained from rAAV stocks puri ed by CsCl ultracentrifugation or immunoaffnity chromatography revealed that baculoviral and cellular DNA correspond to ≤1.5% and ≤0.02% of the total reads, respectively. Moreover, the sequencing coverage showed that the proximity to the ITRs increases progressively the probability for baculoviral DNA to be encapsidated. Nonetheless, these baculovirus-derived reads are found at a frequency of 2-3 logs lower than the rAAV genome reads. The development of accurate quality control methods is not only critical for fulfilling regulatory requirements, but will also provide novel insights into the biological mechanism of rAAV assembly in insect cells. This movie has been recorded by ICGEB Trieste.

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Matthew Taylor, Adult Clinical Genetics, Department of Medicine UCHSC, Cardiovascular Institute, University of Colorado, USA speaks on " Big Hearts and Bigger Exomes: Next Generation DNA Sequencing in Cardiomyopathies". This seminar has been recorded by ICGEB Trieste
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Regenerative Medicine and Gene Therapy - F. Mavilio - Gene Therapy of Inherited Neuromuscular Diseases
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06/12/16 • 54 min

Fulvio MAVILIO, Genethon, Evry - FRANCE speaks on "Gene Therapy of Inherited Neuromuscular Diseases". This seminar has been recorded by ICGEB Trieste
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FAQ

How many episodes does Regenerative Medicine and Gene Therapy have?

Regenerative Medicine and Gene Therapy currently has 22 episodes available.

What topics does Regenerative Medicine and Gene Therapy cover?

The podcast is about Health & Fitness, Medicine, Therapy, Podcasts and Science.

What is the most popular episode on Regenerative Medicine and Gene Therapy?

The episode title 'A. Barzel - Therapeutic levels of in vivo gene targeting without nucleases' is the most popular.

What is the average episode length on Regenerative Medicine and Gene Therapy?

The average episode length on Regenerative Medicine and Gene Therapy is 45 minutes.

How often are episodes of Regenerative Medicine and Gene Therapy released?

Episodes of Regenerative Medicine and Gene Therapy are typically released every 129 days, 1 hour.

When was the first episode of Regenerative Medicine and Gene Therapy?

The first episode of Regenerative Medicine and Gene Therapy was released on Jul 9, 2010.

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