Leflunomide Pharmacology
02/25/21 • 12 min
On this episode, I discuss leflunomide pharmacology. It is classified as a DMARD and is primarily used in rheumatoid arthritis.
Leflunomide carries a boxed warning for hepatoxicity. LFTs must be monitored with its use.
Leflunomide can inhibit CYP2C8 which plays an important role in pioglitazone metabolism. Concentrations of pioglitazone can go up on account of this interaction.
TB screening should be done prior to beginning the immunosuppressant leflunomide.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
On this episode, I discuss leflunomide pharmacology. It is classified as a DMARD and is primarily used in rheumatoid arthritis.
Leflunomide carries a boxed warning for hepatoxicity. LFTs must be monitored with its use.
Leflunomide can inhibit CYP2C8 which plays an important role in pioglitazone metabolism. Concentrations of pioglitazone can go up on account of this interaction.
TB screening should be done prior to beginning the immunosuppressant leflunomide.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
Previous Episode
Baclofen Pharmacology
Baclofen is primarily used for its ability to help relieve muscle spasms. I discuss baclofen pharmacology on this podcast episode.
Baclofen should not be abruptly discontinued as it can cause a significant withdrawal reaction whose symptoms may include fever, spasticity, rhabdomyolysis, and death.
While baclofen generally avoids any issues with CYP enzyme interactions, it is eliminated by the kidney. Renal function changes can alter drug concentrations.
Sedation, confusion, dizziness, hypotension, and GI upset are some of the more common adverse effects of baclofen.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
Next Episode
Cyclosporine Pharmacology
On this episode, I discuss cyclosporine pharmacology. This medication is an immunosuppressant used to reduce the risk of transplant rejection.
Cyclosporine has a long list of potential adverse effects such as hyperglycemia, renal impairment, GI toxicity, and hypertriglyceridemia.
Important monitoring parameters for cyclosporine include drug levels, electrolytes, renal function, and blood sugars.
CYP3A4 interactions are critical with cyclosporine. Inhibitors can raise concentrations and inducers can lower concentrations.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
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