Pharmacy to Dose: The Critical Care Podcast

Research Principles for COVID-19

Special Guest: Todd Miano, PharmD, PhD

Show Notes: https://pharmacytodose.files.wordpress.com/2020/04/research-principles-show-notes.pdf

05:19 – Todd’s interest in research/statistics; 09:18 – How Todd analyzes a research article; 24:22 – Why so much low-quality research for COVID-19?; 28:18 – In vitro v. in vivo; 32:34 – Risk of study errors in low-quality research; 45:43 – Publication bias; 51:50 – Interpreting outcome-based studies when patients are still critically ill; 54:46 – Ideal primary outcome for COVID-19 trials; 57:50 – Applying information from international data to US patients; 61:02 – What is the risk of using experimental drug treatments?; 68:54 – Effect of COVID-19 on non-COVID research; 70:33 – Advice for starting COVID-19 research; 73:43 – Research red flags; 75:46 – Keeping up with COVID-19 literature; 79:09 – Quarantine entertainment recommendations

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Life After the ICU: A Personal Experience Special Guest: G. Morgan Jones, PharmD, BCCCP, FCCM

Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/life-after-the-icu-show-notes.pdf

Morgan details his incredible journey after a personal experience with PICS and PICS-F.

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Cerebral Edema Treatment

Special Guest: Aaron Cook, PharmD, BCCCP, BCPS, FCCP, FKSHP, FNCS

Show Notes: https://pharmacytodose.files.wordpress.com/2020/04/treatment-of-cerebral-edema-show-notes.pdf

Guideline Development

06:18 – How did the content and the chairs for this guideline get chosen?; 08:40 – How long were you working on these guidelines?; 09:40 – How are panel members chosen for the guidelines?; 11:20 – Is the research librarian underrated?; 13:31 – GRADE methodology and PICO formatting; 17:24 – Has this changed your research habits or ideas?; 21:40 – Challenges from meeting virtually when developing the guidelines; 23:53 – How were disagreements settled within the working group?

Management of Cerebral Edema

27:45 – Cerebral edema and elevated ICP; 29:22 – Refractory cerebral edema management; 31:59 – How long was the initial question list?; 35:03 – Quality of evidence; 37:58 – Patient subgroup with the most evidence; 40:10 – Should we be driving up patients’ sodium levels?; 44:56 – Is there a preferred hyperosmolar agent?; 47:45 – Mannitol in acute ischemic stroke; 49:00 – Osmolar therapy and neurologic outcomes; 51:16 – HTS administration; 54:30 – HTS ADE and monitoring; 57:10 – Mannitol osmolality monitoring; 58:20 – Hyperosmolar therapy ADE prevention; 61:00 – Guideline key take-aways; 62:20 – Common research issues

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Extracorporeal Membrane Oxygenation (ECMO) Special Guest: Amy Dzierba, PharmD, FCCM, FCCP, BCCCP

Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/ecmo-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2020/01/ecmo-references.pdf

00:25 - #PharmacyToRead Announcement!; 07:50 – Why is Amy interested in ECMO?; 11:48 – What is ECMO and when did we start using ECMO in the US?; 13:45 – ECLS v. ECMO; 15:52 – Why are we talking about ECMO today?; 19:40– What does ECMO do?; 21:05 – ECMO modalities; 22:59 – ECMO equipment; 27:30 – What should be tried before ECMO?; 30:56 – ECLS effect on PK/PD; 40:05 – Tips/tricks on ECMO anticoagulation, infection, and sedation protocols; 40:45 – Anticoagulation protocols; 47:30 – Infection protocols; 53:15 – Sedation protocols; 58:18 – ECMO complications; 60:40 – Tips when creating or modifying ECMO protocols; 63:27 – Future areas of ECMO research; 65:00 – Take-home points

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HRS-AKI & Terlipressin

Special Guest: Stephanie Bass, PharmD, FCCP, BCPS, BCCCP

05:45 – HRS and HRS-AKI diagnosis

17:00 – Albumin and volume status

23:55 – Terlipressin/vasoconstrictor treatment

52:00 – Medication safety considerations

Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/hrsaki-terlipressin-references.pdf

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