Pharm to Table
LC Campeau & Dani Schultz
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Top 10 Pharm to Table Episodes
Goodpods has curated a list of the 10 best Pharm to Table episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to Pharm to Table for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite Pharm to Table episode by adding your comments to the episode page.
08/16/21 • 7 min
ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re brining you 3 good minutes with Ania Fryszkowska, a biocatalysis whiz who recently co-authored an article in Science on innovative biocatalytic cascades to access sugars (link HERE). While this episode is short, we get answers to some serious questions such as “which Nobel laureate zoom-bombed the Virtual Biocatalysis and Protein Engineering Meetups?”; “what does the future of biocatalysis hold?”; and most importantly “cats or dogs?” and “cookies or candy?” - trick questions 😉.
Follow Ania on Twitter - @fryania
Follow the Pharm to Table podcast on Twitter - @PharmToTablePod
Snack: Origin Story
Pharm to Table
07/19/21 • 3 min
Every great meal starts with an inspiration....
Find out how Pharm to Table was created from an idea to our release. You'll find out how we gathered all the essential ingredients - including our name, logo, music and also folks that gave us great advice along the way. You will also get to meet a key early contributor, our Merck Future Talent program intern Jimmy Olsen (now a graduate student with Professor John Wood at Baylor!), who helped us get off the ground last year!
Follow the Pharm to Table podcast on Twitter - @PharmToTablePod
S2.E2: Enabling medicinal chemistry knowledge exchange with #ChemistryWizards (not trolls)
Pharm to Table
12/07/22 • 36 min
For S2E2, we’re joined by drug hunting legends Doug Beshore and Izzat Raheem who recently co-authored a recent (and popular) paper in J. Med. Chem. on building a culture of knowledge exchange.
Ironically, it’s easier to learn through the literature than from your organization, colleagues or group members - especially if colleagues have taken on different roles. As a result, building and maintaining a culture where prior knowledge is easily accessible and updatable is paramount to a healthy learning culture.
In this episode we go into the 4 pillars that made knowledge exchange with Merck Discovery successful, which includes (1) IT; (2) knowledge capture; (3) participation and most importantly (4) culture. Knowledge management is not unique to industry - in fact, many of the lessons learned can be directly applied to an academic culture as well - and span beyond science and into DEI as well. So tune in to hear how simple practices can boost learning and knowledge exchange in your research.
Read the papers we discussed today here:
Building a Culture of Medicinal Chemistry Knowledge Sharing - J. Med. Chem.
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
S3:E4 - "Asta La Vista, Baby" - The Aminator
Pharm to Table
04/22/24 • 21 min
11/01/22 • 32 min
We kick off season 2 with a bang, talking about complex molecule synthesis with John McIntosh and Nastaran Salehi. Cyclic dinucleotides (CDNs) are a total synthesis fan's dream with 10 stereocenters (including 2 at phosphorus) arranged around a 13 membered macrocycle formed by 2 non-canonical nucleosides. These endogenous secondary messenger molecules have attracted attention because of their activation of the immune system via the STING pathway. We go into all aspects of the innovative biocatalytic cascade that the team designed for their synthesis, including: 1) How a bald eagle cyclic guanosine-adenosine synthase (cGAS) was engineered to form the macrocycle; 2) How cGAS was leveraged by medicinal chemists to greatly accelerate drug discovery; 3) How the team strung together and optimized a 4-enzyme cascade to deliver a CDN directly from nucleotide building blocks.
Read the papers we discussed today here:
A kinase-cGAS cascade to synthesize a therapeutic STING activator - Nature
New Mechanism for Cinchona Alkaloid-Catalysis Allows for an Efficient Thiophosphorylation Reaction - J. Am. Chem. Soc.
Follow Nastaran Salehi - @Nastaran198
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
05/22/23 • 31 min
Dr. Becky Ruck joins Dani and LC for the grand finale of our journey reviewing the history of the Merck Catalysis Laboratory. She highlights how her background in physical organic chemistry led to deeper role of understanding mechanism and kinetics in development of reactions - a strength of Becky's which ultimately influenced the direction of the Catalysis group. Becky also gives a forward looking perspective as leader of the Process Research & Development Enabling Technologies organization where her team is taking on small molecules, biologics and vaccines!
Read the paper we discussed today here:
The Catalysis Laboratory at Merck: 20 Years of Catalyzing Innovation - ACS Catalysis
Follow Becky on Twitter - @Ruck_chem
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
02/28/23 • 34 min
For this month's episode, Dani and LC dive into the challenges of strained cyclic peptide synthesis with Niki Patel and Dave Petrone who recently completed the total synthesis of Darobactin A in collaboration with Professor Sarlah's group at UIUC. Now this wasn't Merck's first foray into natural product total synthesis, in fact Darobactin A is part of a rich legacy of total syntheses at Merck that spans 80 years!
Niki and Dave share how the internal Merck team first envisioned putting this molecule together - including how to construct the complex non-canonical amino acids and ultimately how to forge the highly strained bis-macrolactams. They then walk us through how the team ended up collaborating with Professor Sarlah's team at UIUC combining efforts to complete the total synthesis. Niki, Dave, and Professor Sarlah describe that first meeting and share how they ultimately overcame the macrocyclization challenges which resulted in the total synthesis of Darobactin A!
This episode is filled lots of learnings which include how to construct strained cyclic peptide but more importantly, how a strong network can elevate problem solving and potentially lead to a fruitful academic-industrial collaboration.
Read the paper we discussed today here:
Total Synthesis of Darobactin A - JACS
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
S2 Kickoff: Answering Your Questions & S2 Sneak Peak
Pharm to Table
10/24/22 • 10 min
For our kickoff of Season 2, LC and Dani get together (in person!) to reflect on what’s changed since the Pharm to Table pod started in late 2020, answer a listener question (only 9 months late!) on whether a postdoc is needed for an industrial job, and give a sneak peak on what’s to come for Season 2.
Whether you listen in the car or in the lab - buckle up and don that PPE - as Season 2 is destined to be full of energy, laughs and awesome #MerckChemistry.
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
04/24/23 • 10 min
L.-C. and Dani talk about the next era in the Catalysis Lab's evolution, highlighting the democratization of high-throughput experimentation tools for end-users and the development of nanomole-scale HTE. It was also in this period that the Catalysis Laboratory's expanded its capabilities in photochemistry developing screening tools to invent and scale-up novel photochemical synthetic methods, including decatungstate mediate reactions and photoredox catalysis.
Read the paper we discussed today here:
The Catalysis Laboratory at Merck: 20 Years of Catalyzing Innovation - ACS Catalysis Nanomole-scale high-throughput chemistry for the synthesis of complex molecules - Science Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides - JACS A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions - Chemical Science Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib - Organic Letters
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://anchor.fm/pharm-to-table
S3:E2 - Barton-McCombie Beware!
Pharm to Table
01/15/24 • 34 min
Charles Yeung (@Charles_chem) joins the pod to share some of the latest results from a collaboration with Prof. Wickens' lab (@WickensGroup) at the University of Wisconsin Madison. In their latest paper published in Angewandte Chemie, they disclose a practical and general protocol for alcohol dehydrogenation - putting the Barton-McCombie on notice! The work was supported by a Merck post-doctoral fellow, Myriam Mikhael (@MyriaMikhael), who shares her experience as an industrial PDF.
Read the papers we discussed today:
Practical and General Alcohol Deoxygenation Protocol - ACIE
Translating Planar Heterocycles into Three-Dimensional Analogs by Photoinduced Hydrocarboxylation - ACIE
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
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FAQ
How many episodes does Pharm to Table have?
Pharm to Table currently has 44 episodes available.
What topics does Pharm to Table cover?
The podcast is about Chemistry, Podcasts and Science.
What is the most popular episode on Pharm to Table?
The episode title 'S3:E4 - "Asta La Vista, Baby" - The Aminator' is the most popular.
What is the average episode length on Pharm to Table?
The average episode length on Pharm to Table is 23 minutes.
How often are episodes of Pharm to Table released?
Episodes of Pharm to Table are typically released every 20 days, 21 hours.
When was the first episode of Pharm to Table?
The first episode of Pharm to Table was released on Jun 17, 2021.
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