PeerView Gastroenterology CME/CNE/CPE Audio Podcast - Kurt Schalper, MD, PhD - Leveraging Biomarkers to Guide Candidate Selection for Cancer Immunotherapies: Precision is Paramount, Collaboration is Crucial

Kurt Schalper, MD, PhD - Leveraging Biomarkers to Guide Candidate Selection for Cancer Immunotherapies: Precision is Paramount, Collaboration is Crucial

04/01/20 • 82 min

PeerView Gastroenterology CME/CNE/CPE Audio Podcast

Go online to PeerView.com/Precision20?Promocode=860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Cancer immunotherapies are demonstrating remarkable clinical activity in an increasing number of malignancies, and as the immunotherapy arsenal has continued to expand, it has become clear that reliable biomarkers are needed to guide clinical decisions regarding treatment selection and identification of patients who are most likely to benefit from specific agents or immune-based combinations. A number of proven and putative biomarkers have been and continue to be evaluated, including PD-L1 expression, MSI/MMR, and others. Testing for these biomarkers has significant implications for pathology practice. This PeerView Live Seminars and Tumor Board symposium will provide participating pathology professionals with evidence-based and practical expert instruction on biomarker testing in the era of precision cancer immunotherapy. In the Seminars segments, our expert panel will review evidence on current and emerging immunotherapies and biomarkers, and the Tumor Board will focus on the nuances of applying this evidence to pathology practice, as well as strategies for collaborating with oncology professionals in interpreting biomarker testing results when making clinical decisions for patients with cancer. Upon completion of this activity, participants should be better able to: Characterize the efficacy/safety profiles and clinical roles of current and emerging immunotherapies and combinations across different malignancies, along with relevant biomarker alignments, Evaluate the latest evidence supporting the use of PD-L1, MSI/MMR, TMB, and other emerging biomarkers and multiparametric approaches as predictors of benefit from cancer immunotherapies, Discuss the practical aspects of immunotherapy biomarker testing and interpretation in pathology practice, including companion diagnostic use requirements, benefits/limitations of different testing methodologies, assays, cutpoints, and other nuances, Implement best practices for cancer immunotherapy biomarker testing and interpretation in collaboration with oncologists and other relevant professionals to guide and refine the use of cancer immunotherapies in current practice

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undefined - Manish A. Shah , MD - Evidence and Practicalities: Checkpoint Inhibition in Gastrointestinal Cancers—Translating Recent Advances in Gastric, Esophageal, and Colorectal Cancers

Manish A. Shah , MD - Evidence and Practicalities: Checkpoint Inhibition in Gastrointestinal Cancers—Translating Recent Advances in Gastric, Esophageal, and Colorectal Cancers

Go online to PeerView.com/BJU860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Immune checkpoint inhibitors have become essential components of the treatment arsenal for gastrointestinal (GI) cancers, and ongoing studies are expected to further refine and expand their role. This video features a MasterClass from the 2020 GI Cancers Meeting in San Francisco where top GI specialists assessed the current state of the science and future potential of immunotherapies and combination treatments, and offered practical guidance in the integration and use of immunotherapies in gastric, esophageal, and colorectal cancers. Don’t miss this discussion so you can better navigate the increasingly complex immunotherapy and biomarker landscape. Upon completion of this activity, participants should be better able to: Describe the rationale for the biomarker-guided use of checkpoint inhibitors, including via testing for PD-L1, MMR/MSI status, and others across the spectrum of GI cancers, Assess the latest safety and efficacy evidence on immune checkpoint inhibitors for patients with advanced gastrointestinal cancers, Examine emerging data regarding the potential of checkpoint inhibitors in combination regimens and in early treatment settings, including first-line and perioperative, for patients with gastrointestinal cancers, Recommend personalized treatment plans incorporating immune checkpoint inhibitors, including possible enrollment in a clinical trial, for eligible patients with advanced gastrointestinal cancers

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undefined - David T. Rubin, MD - Transforming the Management of Inflammatory Bowel Disease: A Closer Look at the Role of JAK Inhibitors and the Patient’s Perspective in Achieving Therapeutic Goals

David T. Rubin, MD - Transforming the Management of Inflammatory Bowel Disease: A Closer Look at the Role of JAK Inhibitors and the Patient’s Perspective in Achieving Therapeutic Goals

Go online to PeerView.com/QDR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The past decade has brought substantial advances in the management of IBD. Nevertheless, under current therapeutic options, half of patients with moderate to severe ulcerative colitis (UC) or Crohn’s disease (CD) fail to achieve sustained remission. After years of IBD treatment dominated by monoclonal antibodies, we are currently witnessing promising developments of small molecules for UC and CD. Among them, Janus kinase (JAK) inhibitors are a promising new class that have demonstrated efficacy with a favorable safety profile in clinical trials. Utilizing a mix of didactic presentations and prerecorded patient videos, this activity based on a live symposium will explore current and emerging treatments and guidelines for UC and CD. The faculty panel provides a thorough examination of current and emerging JAK inhibitors, as well as insight into patient-centered, treat-to-target management approaches in IBD. Upon completion of this activity, participants should be better able to: Examine the burden of illness and unmet needs in patients with inflammatory bowel disease, Summarize efficacy and safety data related to current and emerging JAK inhibitors for the treatment of Crohn’s disease (CD) and ulcerative colitis (UC), Treat CD and UC in accordance with current evidence and guidelines, recognizing the role of non–anti-TNF therapies in inducing and maintaining remission in patients with moderate to severe disease, Incorporate JAK inhibitors into treatment plans for individual patients with CD or UC, recognizing the importance of achieving therapeutic targets and a patient-centered approach to care.