New Books in Neuroscience

Sleep was taking over Anna's life. Despite multiple alarm clocks and powerful stimulants, the young Atlanta lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn't stay awake long enough to eat. Anna's doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.

The Woman Who Couldn't Wake Up: Hypersomnia and the Science of Sleepiness (Columbia UP, 2023) tells Anna's story-and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated and controlled. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna's successful treatment helped others form a community. He shows how a group of patients who felt neglected or dismissed united to steer research toward their little-known disorder.

Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is essential reading for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.

Melek Firat Altay is a neuroscientist, biologist and musician. Her research focuses on deciphering the molecular and cellular mechanisms of neurodegenerative and neurodevelopmental disorders.

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How could you lose your memory overnight, and what would it mean? The day neurologist Jed Barash sees the baffling brain scan of a young patient with devastating amnesia marks the beginning of a quest to answer those questions. First detected in a cluster of stigmatized opioid overdose victims in Massachusetts with severe damage to the hippocampus--the brain's memory center--this rare syndrome reveals how the tragic plight of the unfortunate few can open the door to advances in medical science.

After overcoming initial skepticism that investigating the syndrome is worth the effort--and that fentanyl is the likely culprit--Barash and a growing team of dedicated doctors explore the threat that people who take opioids chronically as prescribed to treat severe pain may gradually put their memories at risk. At the same time, they begin to grasp the potential for this syndrome to shed light on the most elusive memory thief of all--Alzheimer's disease.

Through the prism of this fascinating story, Aguirre goes on to examine how researchers tease out the fundamental nature of memory and the many mysteries still to be solved. Where do memories live? Why do we forget most of what happens in a day but remember some events with stunning clarity years later? How real are our memories? And what purpose do they actually serve?

Perhaps the greatest mystery in The Memory Thief: And the Secrets Behind How We Remember (Pegasus, 2021) is why Alzheimer's has evaded capture for a century even though it afflicts tens of millions around the world and lies in wait for millions more. Aguirre deftly explores this question and reveals promising new strategies and developments that may finally break the long stalemate in the fight against this dreaded disease.

But at its core, Aguirre's genre-bending and deeply-reported book is about paying attention to the things that initially don't make sense--like the amnestic syndrome--and how these mysteries can move science closer to an ever-evolving version of the truth.

The research and writing of The Memory Thief was supported in part by a grant from the Alfred P. Sloan Foundation Program in Public Understanding of Science and Technology.

Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at [email protected].

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Everyone has heard of the term "pseudoscience", typically used to describe something that looks like science, but is somehow false, misleading, or unproven. Many would be able to agree on a list of things that fall under its umbrella-- astrology, phrenology, UFOlogy, creationism, and eugenics might come to mind. But defining what makes these fields "pseudo" is a far more complex issue. It has proved impossible to come up with a simple criterion that enables us to differentiate pseudoscience from genuine science. Given the virulence of contemporary disputes over the denial of climate change and anti-vaccination movements--both of which display allegations of "pseudoscience" on all sides-- there is a clear need to better understand issues of scientific demarcation.

On the Fringe: Where Science Meets Pseudoscience (Oxford UP, 2021) explores the philosophical and historical attempts to address this problem of demarcation. This book argues that by understanding doctrines that are often seen as antithetical to science, we can learn a great deal about how science operated in the past and does today. This exploration raises several questions: How does a doctrine become demonized as pseudoscientific? Who has the authority to make these pronouncements? How is the status of science shaped by political or cultural contexts? How does pseudoscience differ from scientific fraud?

Michael D. Gordin both answers these questions and guides readers along a bewildering array of marginalized doctrines, looking at parapsychology (ESP), Lysenkoism, scientific racism, and alchemy, among others, to better understand the struggle to define what science is and is not, and how the controversies have shifted over the centuries. On the Fringe provides a historical tour through many of these fringe fields in order to provide tools to think deeply about scientific controversies both in the past and in our present.

Marshall Poe is the founder and editor of the New Books Network. He can be reached at [email protected].

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An edgy and ambitious debut by a powerful new voice in contemporary literary fiction Monday, Kierk wakes up. Once a rising star in neuroscience, Kierk Suren is now homeless, broken by his all-consuming quest to find a scientific theory of consciousness. But when he's offered a spot in a prestigious postdoctoral program, he decides to rejoin society and vows not to self-destruct again. Instead of focusing on his work, however, Kierk becomes obsessed with another project--investigating the sudden and suspicious death of a colleague. As his search for truth brings him closer to Carmen Green, another postdoc, their list of suspects grows, along with the sense that something sinister may be happening all around them.

The Revelations (Overlook Press, 2021), not unlike its main character, is ambitious and abrasive, challenging and disarming. Bursting with ideas, ranging from Greek mythology to the dark realities of animal testing, to some of the biggest unanswered questions facing scientists today, The Revelations is written in muscular, hypnotic prose, and its cyclically dreamlike structure pushes the boundaries of literary fiction. Erik Hoel has crafted a stunning debut of rare power--an intense look at cutting-edge science, consciousness, and human connection.

You can find Erik Hoel on Substack at https://erikhoel.substack.com/ and on Twitter @erikphoel.

Joseph Fridman is a researcher, science communicator, media producer, and educational organizer. He lives in Boston with two ragdoll kittens and a climate scientist.You can follow him on Twitter @joseph_fridman, or reach him at his website, https://www.josephfridman.com/.

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Building on work in feminist studies, queer studies and critical race theory, this volume challenges the universality of propositions about human nature, by questioning the boundaries between predominant neurotypes and 'others', including dyslexics, autistics and ADHDers.

Neurodiversity Studies: A New Critical Paradigm (Routledge, 2020) is the first work of its kind to bring cutting-edge research across disciplines to the concept of neurodiversity. It offers in-depth explorations of the themes of cure/prevention/eugenics; neurodivergent wellbeing; cross-neurotype communication; neurodiversity at work; and challenging brain-bound cognition. It analyses the role of neuro-normativity in theorising agency, and a proposal for a new alliance between the Hearing Voices Movement and neurodiversity. In doing so, we contribute to a cultural imperative to redefine what it means to be human. To this end, we propose a new field of enquiry that finds ways to support the inclusion of neurodivergent perspectives in knowledge production, and which questions the theoretical and mythological assumptions that produce the idea of the neurotypical.

Working at the crossroads between sociology, critical psychology, medical humanities, critical disability studies, and critical autism studies, and sharing theoretical ground with critical race studies and critical queer studies, the proposed new field - neurodiversity studies - will be of interest to people working in all these areas.

Christina Anderson Bosch is faculty at the California State University, Fresno. She is curious about + committed to public, inclusive education in pluralistic societies where critical perspectives on questions of social and ecological justice are valued enough to enact material dignity and metaphysical wellbeing on massive scales.

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