#71: Arnold Eiser, MD: Intersections of Neuroscience & Public Health

08/13/22 • 62 min

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Dr Arnold Eiser, MD, MACP trained as a nephrologist over 40 years ago but has come to see that the kidneys, liver and other 'extracranial factors' (influences from outside the cranium, the skull holding the brain) hold some of the most impactful sway over the health of our brains. He's termed this relationship between organ dysfunction in the body to assumed compromise in central nervous system brain neuroinflammation Eiser's Corollary of Related Toxicity. His book, Preserving Brain Health in a Toxic Age: New insights from neuroscience, integrative medicine and public health (Rowman & Littlefield, Oct 2021) explores this topic in depth. He examines the ways in which environmental policy, corporate pollutive behavior, metals, microbes, common medications like acetaminophen (Tylenol), and experiences with digital violence seem to hasten neuroinflammatory changes that can present as our current epidemics of autism and Alzheimer's Disease. It's a multi-tiered attack on the nervous system that our society doesn't loop back to true root causes. The book explores the interface between the chemical environment and industrial and agricultural practices.. He notes almost all neurotoxins are also carcinogenics and recognizes the key role of the liver as a front-line organ for protection or vulnerability for brain inflammation- and then notes the epidemic of non-alcoholic fatty acid disease in the modern world. He notes that CFS/ dysautonomia was originally described in the 1800's as a 'disease of modernity' associated with newspaper printing and rail travel. We then talk about the integrative medicine, high fructose corn syrup, nutrients, spices, and in the process really listing out many of the ways we can make our whole world medicine better at preserving brain health.

Find the book: https://www.amazon.com/Preserving-Brain-Health-Toxic-Age/dp/1538158078

or https://rowman.com/ISBN/9781538158074/Preserving-Brain-Health-in-a-Toxic-Age-New-Insights-from-Neuroscience-Integrative-Medicine-and-Public-Health

Find the book: https://www.amazon.com/Preserving-Brain-Health-Toxic-Age/dp/1538158078

or https://rowman.com/ISBN/9781538158074/Preserving-Brain-Health-in-a-Toxic-Age-New-Insights-from-Neuroscience-Integrative-Medicine-and-Public-Health

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undefined - #70 Dr Tarun Singhal, MD on microglial activation as a common root of neuroinflammatoy conditions but also brain fog, fatigue and mood changes

#70 Dr Tarun Singhal, MD on microglial activation as a common root of neuroinflammatoy conditions but also brain fog, fatigue and mood changes

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Microglial cells are responsible for sensing and driving the immune response in the central nervous system. Their activity, be it supportive or destructive, can be at the root of many different neuroinflammatory conditions including diseases like MS, ALS, Alzheimer’s, Parkinson’s, and TBI (Traumatic Brain Injury), but may also play a large role in the vague hallmark symptoms of complex and chronic disease like brain fog, fatigue, pain, alertness and mood changes including OCD, ADD, and depression.

Dr Singhal systematically walks us through an easily understood description of the types of cells in the brain (neurons, macroglia (astrocytes & oligodendrocytes), microglia) and their functions. The microglia are a fascinating type of neuroimmune cell that sense and act protectively in good times and then can change shape and release various cytokines, chemokine and neurotransmitters in response to the development of disease, which then impacts microglia function further. We used to only be able to see this on autopsy- there are no blood tests available to measure microglial activation (although neurofilament light chains (NfL) from neurons and glial fibrillary acid protein (GFAP) from astrocytes can reflect central nervous system cellular injury).

But PET imaging can visualize microglial activation! Dr Singhal explains in elucidating detail the nature, function, and power of Positron Emission Tomography (PET) imaging, like starting with the Big Bang, anti-matter particles, medical cyclotrons and gamma rays. “PET brings physics, chemistry and biology together in real time to provide novel insights at a cellular and molecular level”, including microglial activation. “If you know yourself and know your enemy, you’ll win 1000 battles” is the way he describes what PET can do for neuroinflammatory conditions.

We end the show with a discussion of treatment theories and options targeting microglial activation. It’s a combination of re-evaluating known therapies (even the old antibiotic minocycline!) for their impact on microglia as well as mention of some novel therapies, including a nasal spray ‘vaccine’ for MS. Of course, we bring up non-pharmacologic therapy potentials including exercise, the Ayurvedic perspective including panchakarma detoxification, the power of breathing to impact cerebrospinal fluid flow, ketogenic diet, and consideration of various adaptogenic herbs with the goal of supporting the immune system’s intelligence.

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#72 Jennifer Bahr, ND: All about Homeopathy and its use for children with PANS/PANDAS

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Dr Jennifer Bahr is a Naturopathic Physician with deep interest, experience and success in treating children using Classical Homeopathy for PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Acute-Onset Neuropsychiatric Disease Associated with Streptococcus).

We start this show with the fascinating story of Homeopathy- history, mechanisms and current practice around the world. The American Institute of Homeopathy (AIH) was actually the first medical society formed in the United States in 1844. The Homeopathic Pharmacopeia of the United States, still regulated by the FDA, recognizes over 1000 remedies. Research first published in 2010 used scanning microscopy to identify nanoparticles of a homeopathic remedy’s plant, animal and mineral sources in what is so ultra-diluted that it was previously considered nearly nothing (smaller than Avogadro’s number!). With this same technology, it can be measured that there are physiological changes like tiny like nudges that can impart significant trajectory changes in a child’s health.

Then we dive into PANS/PANDAS. Although there is more research about PANDAS (meaning symptoms associated with strep infection), triggers can be well beyond Strep, which is the nature of the condition known as PANS. Children can present with debilitating fear, rage, sleep disruptions, intense separation anxiety, reading/ math regression, toilet training regressions, distinct behavioral changes, tics, avoidant-restrictive food disorder, and OCD (obsessive-compulsive disorder). It’s thought to happen in relation to an infective insult, but this may be so subtle as to not even be recognized (even mold in a home). PANS and PANDAS can be thought of as an immune system susceptibility; Homeopathy addresses susceptibilities to repair the biochemical patterns in realms that conventional medicine does not yet operate.

This is an incredible show that gives an excellent introduction to Homeopathy as well treatment possibilities for children and families truly suffering with these severe, often inconsolable, symptoms. We recorded this show with Dr Bahr precisely because of the results we are seeing in clinic with patients who have engaged with the Resilience Naturopathic team (demand is so great she has 16 clinicians on her team that see patients remotely around the world). Throughout the show, she weaves through her personal story, which is so insightful for both process and progress, but also demonstrates how life can feel in an effective treatment vacuum.

Please listen in and share widely.

Find out more about her, Resilience Naturopathic and PANS/PANDAS at the resources below.

Resilience Naturopathic

p: 858-461-8121

a: 3633 Camino Del Rio South, Suite 103 San Diego, CA, 92108

w: www.resiliencenaturopathic.com

e: [email protected]
Join our FREE FB Group for our free mini course on PANS/ PANDAS solutions and lots of great conversation and support!

YouTube Channel for Resilience Naturopathic.