NEJM This Week

Featuring articles on Covid-19 after vaccination and previous infection, vaccination after recovery from SARS-CoV-2 infection, mini-slings for stress incontinence in women, higher-dose primaquine for P. vivax malaria, and on how medicine is not gender-neutral; a review article on decompression sickness and arterial gas embolism; a case report of a man with marked ventricular wall thickening; and Perspective articles on restrictive state abortion bans, on when patients go to court for unproven treatments, and on epidemiology and the Faroe Islands.

Featuring articles on a randomized trial of a pan-PPAR agonist in NASH, outcomes in nonalcoholic fatty liver disease, the AQP1 promoter variant and peritoneal dialysis, obesity in childhood and GNAS mutations, and optogenetics recognized through the Lasker Award; a review article on point-of-care ultrasonography; a case report of a girl with swelling of the jaw and hypercalcemia; and Perspective articles on blood donation by gay and bisexual men, on the case for wage equity for essential health care workers, and on peak moments.

Featuring articles on shorter-course TB treatment in children, thyroidectomy without radioiodine, Covid-19 vaccine effectiveness in North Carolina, ribociclib in hormone receptor–positive breast cancer, the effects of boosters after Ad26.COV2.S vaccination, and on tumors and T cells; a review article on extracorporeal kidney-replacement therapy for acute kidney injury; a case report of a woman with depression, recurrent falls, and inability to care for herself; and Perspective articles on step therapy’s balancing act, on coverage of transvenous pulmonary embolectomy, and on the catfish king.

Featuring articles on frexalimab in multiple sclerosis, e-cigarettes for smoking cessation, cefepime–taniborbactam for complicated UTI, and the treatment of Wolman’s disease in an infant; review articles on treatment-resistant depression in older adults and on Behçet’s syndrome; a case report of a man with fevers; and Perspective articles on ethical issues in safety-net health systems, on secondary cancers after CAR T-cell therapy, and on being worried about white-cell counts.

Featuring articles on the duration of adjuvant therapy in breast cancer, tofacitinib for Covid-19 pneumonia, complications in youth-onset type 2 diabetes, a small-molecule SMN2 modifier in type 1 spinal muscular atrophy, a hyperimmune globulin to prevent congenital cytomegalovirus, and scarless wound healing; a review article on depression in adolescents; a case report of a woman with bloody stools and thrombocytopenia; and Perspective articles on from crime to care, on health care budgets for rural providers, on identifying and tracking SARS-CoV-2 variants, and on a child’s loss.