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Microbe Mail - HIV in South Africa: Part 2

HIV in South Africa: Part 2

04/16/24 • 29 min

Microbe Mail

Professor Francois Venter is back in Part 3 of our HIV series in which he continues to address South Africa's battles against HIV. Here he discusses his experience on how and when to initiate antiretroviral therapy, prophylaxis against opportunistic infection, routine monitoring and what the future of HIV management looks like in South Africa.

About our Guest:

Professor WD Francois Venter, MD, FCP, PhD is Executive Director of Wits Ezintsha at the University of the Witwatersrand, Johannesburg, where he received most of his training. His work involves health systems research and clinical trials, most recently involving the antiretrovirals dolutegravir, tenofovir alafenamide, cabotegravir, and doravirine. He leads multiple antiretroviral treatment optimisation studies and is currently working on new access programmes through private pharmacies within South Africa, patient linkage-to-care interventions, self-testing projects, as well as most recently on new large-scale primary care delivery platforms addressing hypertension, diabetes, obesity, hyperlipidaemia and HIV. He has led large PEPFAR-funded HIV programmes in South Africa, focusing on men, women, children, young people, truckers, sex workers, and LGBTI communities. For over 20 years he has been an advisor to bodies such as the South African government, UNAIDS, and WHO, contributing to international, regional, and national HIV guidelines, and recently served as a member of the Ministerial Advisory Committee for COVID-19. He has an active interest in medical ethics and has been involved in several HIV-related human rights cases within the southern African region. He supervises Masters and PhD students and has over 200 publications, including first-author articles in major journals.

Resources:

SA HIV Clinicians society

ADVANCE STUDY

Southern African HIV Clinicians Society guidelines for antiretroviral therapy in adults:2023 update

Liverpool HIV Drug Interactions Checker

Visit the Microbe Mail website to sign up for updates

Follow on:

Instagram: Microbe_Mail

X/Twitter: @microbemail

Facebook: MicrobeMail

Tiktok: @microbe.mail

Watch this episode on YouTube: Microbe Mail

E-mail us: [email protected]

WE'D LOVE YOUR FEEDBACK ON THIS EPISODE!

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Professor Francois Venter is back in Part 3 of our HIV series in which he continues to address South Africa's battles against HIV. Here he discusses his experience on how and when to initiate antiretroviral therapy, prophylaxis against opportunistic infection, routine monitoring and what the future of HIV management looks like in South Africa.

About our Guest:

Professor WD Francois Venter, MD, FCP, PhD is Executive Director of Wits Ezintsha at the University of the Witwatersrand, Johannesburg, where he received most of his training. His work involves health systems research and clinical trials, most recently involving the antiretrovirals dolutegravir, tenofovir alafenamide, cabotegravir, and doravirine. He leads multiple antiretroviral treatment optimisation studies and is currently working on new access programmes through private pharmacies within South Africa, patient linkage-to-care interventions, self-testing projects, as well as most recently on new large-scale primary care delivery platforms addressing hypertension, diabetes, obesity, hyperlipidaemia and HIV. He has led large PEPFAR-funded HIV programmes in South Africa, focusing on men, women, children, young people, truckers, sex workers, and LGBTI communities. For over 20 years he has been an advisor to bodies such as the South African government, UNAIDS, and WHO, contributing to international, regional, and national HIV guidelines, and recently served as a member of the Ministerial Advisory Committee for COVID-19. He has an active interest in medical ethics and has been involved in several HIV-related human rights cases within the southern African region. He supervises Masters and PhD students and has over 200 publications, including first-author articles in major journals.

Resources:

SA HIV Clinicians society

ADVANCE STUDY

Southern African HIV Clinicians Society guidelines for antiretroviral therapy in adults:2023 update

Liverpool HIV Drug Interactions Checker

Visit the Microbe Mail website to sign up for updates

Follow on:

Instagram: Microbe_Mail

X/Twitter: @microbemail

Facebook: MicrobeMail

Tiktok: @microbe.mail

Watch this episode on YouTube: Microbe Mail

E-mail us: [email protected]

WE'D LOVE YOUR FEEDBACK ON THIS EPISODE!

Previous Episode

undefined - HIV in South Africa: Part 1

HIV in South Africa: Part 1

Part 2 of our HIV series addresses South Africa's battles against HIV as we get an account of the complexities of diagnosis, prophylaxis, and managing opportunistic infections from a celebrated HIV clinician, Professor Francois Venter.

About our Guest:

Professor WD Francois Venter, MD, FCP, PhD is Executive Director of Wits Ezintsha at the University of the Witwatersrand, Johannesburg, where he received most of his training. His work involves health systems research and clinical trials, most recently involving the antiretrovirals dolutegravir, tenofovir alafenamide, cabotegravir, and doravirine. He leads multiple antiretroviral treatment optimisation studies and is currently working on new access programmes through private pharmacies within South Africa, patient linkage-to-care interventions, self-testing projects, as well as most recently on new large-scale primary care delivery platforms addressing hypertension, diabetes, obesity, hyperlipidaemia and HIV. He has led large PEPFAR-funded HIV programmes in South Africa, focusing on men, women, children, young people, truckers, sex workers, and LGBTI communities. For over 20 years he has been an advisor to bodies such as the South African government, UNAIDS, and WHO, contributing to international, regional, and national HIV guidelines, and recently served as a member of the Ministerial Advisory Committee for COVID-19. He has an active interest in medical ethics and has been involved in several HIV-related human rights cases within the southern African region. He supervises Masters and PhD students and has over 200 publications, including first-author articles in major journals.

Resources:

SA HIV Clinicians society website

PrEP guidelines

PEP guidelines

Visit the Microbe Mail website to sign up for updates

Follow on:

Instagram: Microbe_Mail

X/Twitter: @microbemail

Facebook: MicrobeMail

Tiktok: @microbe.mail

Watch this episode on YouTube: Microbe Mail

E-mail us: [email protected]

WE'D LOVE YOUR FEEDBACK ON THIS EPISODE!

Next Episode

undefined - Appropriate use of β-lactam - β-lactamase inhibitor combination antibiotics

Appropriate use of β-lactam - β-lactamase inhibitor combination antibiotics

The rampant emergence of antimicrobial resistance, particularly amongst Gram negative organisms, has called for both the discovery of novel agents but also for a review of therapeutics thought to have been long lost in this battle. Enter, the "BLBLIs or BLICs'. In this episode Vin and Ruan speak with the 1st author of the publication "Appropriate use of the new β-lactam - β-lactamase inhibitor combination agents: Ceftazidime-avibactam and Ceftolozane-tazobactam in South Africa", Professor Adrian Brink, and receive a welcomed masterclass on this interesting group of antimicrobials.

About our Guest:

Professor Adrian Brink is Head of the Division: Medical Microbiology, and member of the Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town and the National Health Laboratory Services, Groote Schuur hospital, Cape Town, South Africa.

Prof Brink was founding President of the Federation of Infectious Diseases Societies of Southern Africa and is the founder and currently co-chairs the South African Antibiotic Stewardship Program (SAASP). Prof Brink currently serves on the South African Minister of Health’s Ministerial Advisory Committee (MAC) on Antimicrobial Resistance and representing Africa, is a member of the European Society of Clinical Microbiology and Infectious Diseases International Affairs Subcommittee.

His is main research interests are the clinical and molecular epidemiology of antibiotic-resistant infections, the mechanisms of resistance as a confounder in antibiotic stewardship, the design and implementation of large-scale antibiotic stewardship, diagnostic stewardship and infection prevention and control interventions in low- and middle-income countries. His interests also include the protective, metabolic and immune functions of the gastrointestinal and vaginal biome including the resistome and metabolome.

Resources from this episode

Best practices: Appropriate use of Beta-lactam/Beta-lactamase inhibitor combinations Ceftazidime-Avibactam and Ceftolozane-Tazobactam)

WHO Priority Pathogens List

Table 1: Data on inhibitor classes, inhibitory mechanisms, and current clinical trial status, Kar D et al., 2023.

Table 6: β-lactam/β-lactamase inhibitor (BL/BLI) combinations in clinical trials or submitted for regulatory approval, Butler et al., 2023

Visit the Microbe Mail website to sign up for updates

Follow on:

Instagram: Microbe_Mail

X/Twitter: @microbemail

Facebook: MicrobeMail

Tiktok: @microbe.mail

Watch this episode on our new YouTube channel: Microbe Mail

E-mail us: [email protected]

-WE'D LOVE YOUR FEEDBACK ON THIS EPISODE –

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