Ep 61: Guest Inge Marie Svane

03/12/25 • 24 min

1 Listener

Summary

In this episode of Melanoma Matters, host Sapna Patel and James Larkin welcome guest Inge Marie Svane to discuss the evolution and future of cancer immunotherapy, particularly focusing on cellular therapy for melanoma. Inge Marie shares her extensive background in the field, the establishment of a cancer immune therapy center in Denmark, and the historical context of cellular therapy. The conversation delves into the current challenges and innovations in T-cell therapy, regulatory hurdles, and the potential for cellular therapy in other solid tumors. The episode highlights the importance of optimizing treatment strategies and the need for collaboration between academia and industry and regulators to improve patient outcomes.

Keywords

melanoma, cancer immunotherapy, cellular therapy, T-cell therapy, checkpoint inhibitors, clinical trials, patient care, regulatory challenges, cancer vaccines, treatment advancements

Takeaways

Inge Marie Svane has over 25 years of experience in cancer immunotherapy.
She established a center for cancer immune therapy in Denmark.
T-cell therapy can benefit patients regardless of checkpoint inhibitor response.
Not all patients are suitable for T-cell therapy; age and health status matter.
Optimizing T-cell manufacturing processes is crucial for efficacy.
Reducing side effects of T-cell therapy is a priority.
Regulatory frameworks for cellular therapy are challenging in Europe.
Future strategies may include genetic modifications to enhance T-cell function.
Cellular therapy shows promise in other solid tumors, but challenges remain.

Titles

Exploring the Future of Melanoma Treatment

Inge Marie Svane on Cancer Immunotherapy Innovations

Sound Bites

"We need to move forward in all directions."

"The system is completely untrained for academia."

Chapters

00:00 Introduction of Guest Inge Marie Svane

05:37 Historical Perspective on Cellular Therapy for Melanoma

09:04 Optimizing T-Cell Therapy: Challenges and Innovations

20:50 Prospects for Cellular Therapy in Other Solid Tumors

Summary

Keywords

melanoma, cancer immunotherapy, cellular therapy, T-cell therapy, checkpoint inhibitors, clinical trials, patient care, regulatory challenges, cancer vaccines, treatment advancements

Takeaways

Inge Marie Svane has over 25 years of experience in cancer immunotherapy.
She established a center for cancer immune therapy in Denmark.
T-cell therapy can benefit patients regardless of checkpoint inhibitor response.
Not all patients are suitable for T-cell therapy; age and health status matter.
Optimizing T-cell manufacturing processes is crucial for efficacy.
Reducing side effects of T-cell therapy is a priority.
Regulatory frameworks for cellular therapy are challenging in Europe.
Future strategies may include genetic modifications to enhance T-cell function.
Cellular therapy shows promise in other solid tumors, but challenges remain.

Titles

Exploring the Future of Melanoma Treatment

Inge Marie Svane on Cancer Immunotherapy Innovations

Sound Bites

"We need to move forward in all directions."

"The system is completely untrained for academia."

Chapters

00:00 Introduction of Guest Inge Marie Svane

05:37 Historical Perspective on Cellular Therapy for Melanoma

09:04 Optimizing T-Cell Therapy: Challenges and Innovations

20:50 Prospects for Cellular Therapy in Other Solid Tumors

Previous Episode

Ep 60: Melanoma & Kidney Cancer w/ Mike Atkins

Welcome to Season 2!

In this episode of Melanoma Matters, hosts Sapna Patel and James Larkin engage with Michael Atkins from Georgetown University to discuss the advancements in melanoma and kidney cancer treatments, particularly focusing on immunotherapy and cytokine treatments. They explore the groundbreaking DreamSeq trial that compares immunotherapy and targeted therapy in 1L melanoma.

Keywords

melanoma, immunotherapy, cytokines, DreamSeq trial, kidney cancer, cancer treatment, checkpoint inhibitors, complete response, T cells, cancer research

Takeaways

The introduction of checkpoint inhibitors has revolutionized cancer treatment.

Cytokines like IL-2 have a historical role but are being reevaluated in modern therapy.

Complete responses to therapy are crucial for durable benefits in cancer treatment.

The DreamSeq trial highlights the superiority of immunotherapy over targeted therapy in certain patient populations.

Understanding the tumor microenvironment is key to improving immunotherapy outcomes.

The need for better imaging techniques to assess treatment responses is critical.

Aggressive disease patients may require different treatment strategies than those with less aggressive disease.

The importance of patient advocacy in pushing for effective cancer treatments.

Future research should focus on enhancing the efficacy of immunotherapy in various cancers.

Sound Bites

"I love talking about melanoma and immunotherapy."

"Immunotherapy was better in all the subgroups."

"We need to raise the bar above nivo-IPI."

Chapters

00:00 Introduction to Melanoma and Immunotherapy

10:21 The Role of Cytokines in Cancer Treatment

17:02 The DreamSeq Trial Explained

27:20 Comparing Immunotherapy and Targeted Therapy in Kidney Cancer

37:18 Final Thoughts on Immunotherapy's Future

Next Episode

Ep 62: Post PD-1 studies

Summary

On mountain emergencies...Sapna's had them, James denies them...This conversation delves into the treatment options available for patients with advanced melanoma who have progressed after anti PD-1 therapy. The discussion covers various clinical studies, response rates, and the implications of combination therapy post-PD1 progression. James and Sapna conclude that while combination therapies show promise, the responses may not be as robust as those seen in frontline treatments.

Keywords

melanoma, PD-1, treatment, clinical trials, immunotherapy, BRAF, response rates, efficacy, combination therapy, patient outcomes

Takeaways

The conversation focuses on treatment options after PD-1 progression.

Clinical studies provide valuable data on post-PD-1 therapies.

Response rates for combination therapies are generally higher than monotherapy.

BRAF status is a critical factor in treatment decisions.

Randomized studies help clarify the efficacy of different treatment approaches.

Combination therapy may offer better outcomes for patients post-PD-1.

Acquired resistance remains a challenge.

Titles

Exploring Treatment Options Beyond PD-1

The Role of Clinical Trials in Melanoma Therapy

Sound Bites

"What to do post PD-1 exposure?"

"Can you get a response to IPI after PD-1?"

"The primary endpoint was PFS, not ORR... "

Chapters

00:00 Opening theme music (My Favourite Dress by The Wedding Present)

01:25 Mountain rescue quickfire

03:08 Post anti-PD1 studies - the issues

04:13 Pires da Silva retrospective study

08:53 Olson single-arm prospective study (and yes we see you Jason)

10:38 SWOG S1616 randomized ph 2 study

16:35 Conclusions

17:17 Fact Check

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