Top 10 Take-home Messages From the 2018 ACC/AHA Cholesterol Guidelines

12/15/21 • 21 min

Drs Laurence Sperling and Neil Stone put key messages from the 2018 cholesterol guidelines into a clear clinical context.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/958747). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol https://www.ahajournals.org/doi/10.1161/CIR.0000000000000625

ASCVD Risk Estimator Plus https://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate/

2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia https://www.jacc.org/doi/10.1016/j.jacc.2021.06.011

What Do US Physicians and Patients Think About Lipid‐Lowering Therapy and Goals of Treatment? Results From the GOULD Registry https://www.ahajournals.org/doi/10.1161/JAHA.120.020893

Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled n-of-1 Trials https://www.bmj.com/content/372/bmj.n135

Drs Laurence Sperling and Neil Stone put key messages from the 2018 cholesterol guidelines into a clear clinical context.

Resources

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol https://www.ahajournals.org/doi/10.1161/CIR.0000000000000625

ASCVD Risk Estimator Plus https://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate/

2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia https://www.jacc.org/doi/10.1016/j.jacc.2021.06.011

What Do US Physicians and Patients Think About Lipid‐Lowering Therapy and Goals of Treatment? Results From the GOULD Registry https://www.ahajournals.org/doi/10.1161/JAHA.120.020893

Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled n-of-1 Trials https://www.bmj.com/content/372/bmj.n135

Previous Episode

How to Improve Dyslipidemia Care in Underresourced Populations

Drs Larry Sperling and Karol Watson discuss health equity and social determinants of health for populations with dyslipidemia.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/958746). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000625

Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease https://www.ahajournals.org/doi/10.1161/CIR.0000000000000638

New AMA Policies Recognize Race as a Social, Not Biological, Construct https://www.ama-assn.org/press-center/press-releases/new-ama-policies-recognize-race-social-not-biological-construct

Race/Ethnicity, Neighborhood Socioeconomic Status and Cardio-metabolic Risk https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397689/

Disparities in Hypertension and Cardiovascular Disease in Blacks: The Critical Role of Medication Adherence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638710/

Racial and Ethnic Disparities in Heart and Cerebrovascular Disease Deaths During the COVID-19 Pandemic in the United States https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191372/

Next Episode

A Natural Winner: Plant-Based Diets and Statins vs Dyslipidemia Risk

In this episode, Dr Laurence Sperling talks with Dr Kim Williams about preventive cardiology nutrition intervention as a key co-therapy for tackling dyslipidemia.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/958748). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

Exercise and CVD Mortality

Associations of specific types of sports and exercise with all-cause and cardiovascular-disease mortality: a cohort study of 80,306 British adults https://bjsm.bmj.com/content/51/10/812#T3

Diet and Dietary Patterns

The reasons for geographic and racial differences in stroke study: objectives and design https://pubmed.ncbi.nlm.nih.gov/15990444/

Heart disease and stroke https://www.cdc.gov/chronicdisease/resources/publications/factsheets/heart-disease-stroke.htm

Effects of ketogenic diets on cardiovascular risk factors: evidence from animal and human studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452247/

Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000510

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext

Intensive lifestyle changes for reversal of coronary heart disease https://pubmed.ncbi.nlm.nih.gov/9863851/

Dietary adherence and acceptability of five different diets, including vegan and vegetarian diets, for weight loss: the New DIETs study https://www.sciencedirect.com/science/article/abs/pii/S147101531500080X

Guidelines and Population Studies

2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk https://academic.oup.com/eurheartj/article/41/1/111/5556353

TMAO

Trimethylamine-N-oxide (TMAO) predicts cardiovascular mortality in peripheral artery disease https://www.nature.com/articles/s41598-019-52082-z

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway https://pubmed.ncbi.nlm.nih.gov/34139173/

Statin Adverse Effects

Effects of coenzyme Q10 on statin‐induced myopathy: an updated meta‐analysis of randomized controlled trials https://www.ahajournals.org/doi/10.1161/JAHA.118.009835

N-of-1 trial of a statin, placebo, or no treatment to assess side effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173