Listen In - Bitesize Bio Webinar Audios

The brain is an immune-privileged organ, meaning it is protected from the entry of pathogens, blood circulating factors, and immune cells by a physical barrier called the blood-brain barrier (BBB).

But pathological events such as ischemia (stroke), trauma (traumatic brain injury), or tumor growth (gliomas and brain metastasis), activate the vascular endothelium, disturb or disrupt the BBB and allow immune cell homing.

In this episode, discover how innate immunity can sustain deleterious effects following brain trauma, and the technological developments enabling longitudinal studies into post-trauma lesion remodeling.

Watch the full presentation here: https://microscopyfocus.com/windows-on-neurovascular-pathologies/

Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Join Kate Christian as she demystifies the process of effectively communicating your research in the latest episode of Listen In.

She describes the impact of research communication in and out of the lab and provides some guides to explaining your research in various contexts, such as lab tours, community visits, and other public engagements.

As well as learning how to work out your h-index, you will learn how to describe the impact of your papers.

Watch the full presentation here: https://events.bitesizebio.com/how-to-effectively-communicate-your-1/join

Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

In this webinar you will learn the tips and tricks necessary for you to successfully work with miRNAs, and how you can use them to further your research. The main points we will cover are: Tips and practical advice to help you work with miRNAs, including isolation and delivery The biology and mechanism of miRNAs and why this matters to your research An example of how miRNAs are being used in disease research. The presenter will take you through the identification of certain aberrantly expressed ones in breast cancer and how they might be used as therapeutic agents. How you can identify important miRNAs in your samples—including tumor cells Practical tips, applications and advice for miRNA research Dr. Brian Adams is a researcher on the leading edge of miRNA research. Join him in this webinar as he demystifies working with miRNAs and gives you his best tips and tricks for working with them in your research. Since Drs. Andrew Fire and Craig Mello won the Nobel Prize for their work on small RNAs, the field has exploded with possibilities and has spawned several vibrant research areas. Brian’s own research examines the role of miRNAs in breast cancer, and the potential therapeutic opportunities they offer. He will discuss how he has identified several ones that are aberrantly expressed in triple-negative breast cancer, for which there is currently no targeted treatment options available, how reintroducing these particular ones can promote anti-tumorigenic phenotypes, and how they could be used to sensitize tumors to chemotherapeutic agents as well as gamma-irradiation. Using this research story as an example Brian will provide you with practical, hands-on advice that will help you get better results with miRNA isolation and delivery in your experiments. He’ll also guide you through the biology and mechanisms of action of and explain the potential therapeutic applications. Learn more about the full potential of miRNAs and find out all the inside tricks for working with them to take your research to the next level. For more information.

For more information visit: https://bitesizebio.com/webinar/all-about-mirnas-practical-tips-advice-and-applications/

Join Dr. Jason Reed as he describes a novel method by which endonuclease-inhibited Cas9 can be employed as a programmable biomarker in high-speed atomic force microscopy (HS-AFM) imaging.

In this webinar, you will learn:

1. How CRISPR/Cas9 can be used to “flag” alterations and mutations in DNA, rather than cut it
2. How pairing atomic force microscopy (AFM) with optical equipment found in DVD players can be used to map DNA at a faster rate than traditional DNA sequencing
3. Applications of this technology, particularly in relation to discovering and diagnosing genetic diseases

Since the diameter of the Cas9 molecule is greater than that of DNA, they are easy to locate along the DNA strand. Taking advantage of this, Jason’s lab reported approximately 90% Cas9 binding accuracy to DNA molecules under optimized conditions. The alignment of single-molecule maps with nanoscale resolution becomes far more computationally straightforward than if labels are localized with multi-kb ambiguity. This process yields reduced processing time and cost for assembling a consensus map. Given its single-molecule sensitivity, approximately 15 bp accuracy, and no amplification requirement, Dr. Reed’s novel method is amenable to small sample sizes. This proves to be an advantage in clinical situations where obtaining the almost 10 ?g of DNA required for single-molecule sequencing is extremely difficult—if not impossible!

For more information visit: https://www.youtube.com/watch?v=58LKOQSmbTY

Stress is a universal challenge, and scientists face unique pressures such as impostor syndrome, the demand for positive results, and career uncertainty. These stressors can be overwhelming and often feel beyond our control.

In this episode of Listen In, we explore the various stresses that scientists encounter in their daily lab life and discuss effective strategies to manage them. Learn how to prevent burnout, anxiety, and depression by addressing issues like perfectionism and impostor syndrome. Our expert shares personal insights and practical advice on cultivating a resilient and healthier growth mindset.

Hit play to discover that you're not alone in feeling overwhelmed and that with the right mindset, you can navigate the pressures of a scientific career more effectively.

Watch the full presentation here: https://events.bitesizebio.com/stress-in-the-lab-common-pitfalls-1/join

Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/