JAMA Author Interviews

The HEALEY ALS platform is an innovative first attempt at platform trials in ALS, looking to slow ALS disease progression. Author Sabrina Paganoni, MD, PhD, of Massachusetts General Hospital and Harvard Medical School, discusses results of the first 4 drug regimens from this platform trial and how this study design makes efficient use of resources, with JAMA Deputy Editor Christopher Muth, MD. Related Content:

• Platform Clinical Trials for the Efficient Evaluation of Multiple Treatments
• Pridopidine in Amyotrophic Lateral Sclerosis
• Platform Trials in ALS
• Verdiperstat in Amyotrophic Lateral Sclerosis
• Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis
• CNM-Au8 in Amyotrophic Lateral Sclerosis

Understanding health conditions with the most spending and variation across locations and over time is important for identifying trends, inequalities, and strategies for lowering health spending. Joseph Dieleman, PhD, of the University of Washington speaks with JAMA Associate Editor Karen Joynt Maddox, MD, MPH, about county-level variation in health care spending across the US. Related Content:

• Tracking US Health Care Spending by Health Condition and County

Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps. Related Content:

• Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps
• Enhancing Obstetric Ultrasonography With Artificial Intelligence in Resource-Limited Settings

Certain CD4+ T-cell subtypes play a role in asthma. Characterizing asthma endotypes in diverse groups is important to help develop effective therapies for youth with asthma. Author Juan C. Celedon, MD, DrPH, University of Pittsburgh, Department of Pediatrics, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content:

• Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth

The CAUGHT-CAD randomized clinical trial sought to determine whether a CAC score-informed strategy could slow the progression of coronary plaque volume. Author Thomas H. Marwick of the Baker Heart & Diabetes Institute joins JAMA Associate Editor Pradeep Natarajan to discuss "Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease." Related Content:

• Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
• Cardiac CT Calcium Score
• Coronary Artery Calcium Testing—Too Early, Too Late, Too Often
• Filling the Evidence Gaps Toward a Coronary Artery Calcium-Guided Primary Prevention Strategy