S2.E4: Perfect Form

Explicit content warning

02/28/22 • 29 min

How do we pick how to introduce the right molecule into the body in the right way? Well, there's a lot of things to consider. How was it absorbed into the body? Where and how is it broken down? What's the size of the molecule? What is it treating? And where do we want it to go? There's lots of different questions to determine the right formulation. So today we explore the magic of formulations. Why is it important? How do we decide from a laundry list of different medications formulations And how do we develop new formulations that haven't yet been developed?

Previous Episode

S2.E3: The Big Leap

The process of moving from a potential drug molecule to being on the shelf of a pharmacy is a long and winding journey. On average, from the time the molecule is discovered to when it's actually approved by the FDA, it takes 12 to 15 years. More importantly, it costs close to $1 billion to bring a drug to market. It's also estimated that of the 1000s of molecules that are looked at, only a few will make it to clinical development, and following that, only five to six percent will survive and ended up being submitted for regulatory review. So how do we choose the winning horse? On this episode of the I'm Pharmacy Podcast we talk to Leslie Dan Faculty of Pharmacy researchers Professor Micheline Piquette Miller, Professor Raymond Reilly, and Dr. Jennifer Doucet on just what it takes to conduct translational research, and the excitement of seeing one's research leave the lab.

Next Episode

S2.E5: On Trial

Today, and as we've seen throughout this pandemic, clinical trials are the commonplace for how any new treatment gets approved. It is the gatekeeper to anything getting stocked on the shelves of pharmacies or hospitals. And that's what I want to dive into in this episode. How are trials planned? What does it take to complete one? What are all the different components that go into this gold standard for clinical evidence, the final step before market access. To help answer these questions, we chat with Dr. Rob Van Exan, a veteran of the industry with over 35 years of experience in vaccine development, and Dr. Lee Dupuis, a Clinician Scientist at the Leslie Dan Faculty of Pharmacy and the Hospital for Sick Children.