ID:IOTS - Infectious Disease Insight Of Two Specialists

Catheter-associated UTI: Callum’s nemesis. His white whale. His Sauron. His favourite rant.

Want to know how favourite? Listen on!
Show notes for this episode here

Useful links (see show notes for more)
RICAT study
Chlorhexidine meatal cleaning

Send us a text

Support the show

Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
If you are enjoying the podcast please leave a review on your preferred podcast app!
Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

Join Jame and Callum and they discuss some of the other Enterobacterales Gram negatives. Particularly breaking down them into their families and into Lactose fermenters and non-fermenters. Jame has a small breakdown around our Twitter handle near the end.
Comments suggestions and criticisms to [email protected] or @IDiots_pod
Some lists:
Chromosomal AmpC Carriers (high-risk): HECK YES

· Hafnia alvei, Enterobacter cloacae, Citrobacter freundii, Klebsiella aerogenes, Yersinia enterocolitica

Lower Risk Chromosomal AMPC: Vulgar Providencia Store AMPC

· Proteus Vulgaris, Providencia, Serratia, Acinetobacter, Morganella, Providencia

Intrinsic Colistin Resistance:

· Burkholderia cepacia (Nonfermenter), Proteus, Providencia, Serratia

Biochemical mimics of Salmonella (also can group)

· Hafnia, Morganella,Proteus

Cat 3 organisms:

· Salmonella typhi/paratyphi, Shigella dysenteriae type 1, E.coli O157, Yersinia Pestis

Some useful resources:
SMI ID 16: identification of Enterobacteriaceae

https://www.gov.uk/government/publications/smi-id-16-identification-of-enterobacteriaceae

Janda JM, Abbott SL. 2021. The changing face of the family Enterobacteriaceae (order: “Enterobacterales”): new members, taxonomic issues, geographic expansion, and new diseases and disease syndromes. Clin Microbiol Rev 34:e00174-20.

https://doi.org/10.1128/CMR.00174-20

Send us a text

Support the show

Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
If you are enjoying the podcast please leave a review on your preferred podcast app!
Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

Jame and Callum continue their discuss of the Enterobacterales, looking at Klebsiella spp. with focused discussion on some microbiological history, K1 syndrome, and the pharmacokinetics of antimicrobials for endophthalmitis.
For the graphic Jame suggested look at Figure 4 in this paper: https://academic.oup.com/femsre/article/41/3/252/3830265
Suggestions and comments to [email protected].
If you are enjoying the podcast please leave a review on your preferred podcast app!

Send us a text

Support the show

Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
If you are enjoying the podcast please leave a review on your preferred podcast app!
Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

Join Jame as he continues to talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.
ECDC guidelines

· https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x

· https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0

Canadian guidelines

· https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf

IDSA

https://www.idsociety.org/practice-guideline/amr-guidance-2.0/#

Comparison of IDSA and ESCMID

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00054-4/fulltext

https://amr.solutions/2019/01/13/categories-of-resistance-mdr-xdr-pdr-udr-and-new-dtr/

Send us a text

Support the show

Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
If you are enjoying the podcast please leave a review on your preferred podcast app!
Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

Back after a summer break, Jame and Callum discuss the fascinating machine that is the MALDI-TOF. Matrix Assisted Laser Desorption Ionisation Time Of Flight mass spectrometry. We discuss the basics of how it functions, its application in the lab and some pros and cons of its use along with what the future may hold. Here are some relevant videos and papers:
- Exciting video of MALDI-TOF
https://www.youtube.com/watch?v=0jeFpXHZ8W0&ab_channel=BrukerDaltonics
- MALDI-TOF to detect MRSA https://www.frontiersin.org/articles/10.3389/fmicb.2020.00232/full
- Direct MALDI-TOF on blood cultures
https://www.spandidos-publications.com/10.3892/etm.2020.9365
- MALDI-TOF to detect CPE
https://www.frontiersin.org/articles/10.3389/fmicb.2021.789731/full

Send us a text

Support the show

Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
If you are enjoying the podcast please leave a review on your preferred podcast app!
Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod