HEALTHCARE UNCENSORED: Matthew Holt, Healthcare Curmudgeon

10/21/24 • 48 min

In this episode I am in conversation with Matthew Holt, a prominent figure in health technology and policy; an uncensored discussion on the current state of healthcare. Known for his frank and often controversial opinions, Holt is expected to delve into pressing issues such as the impact of artificial intelligence on medical practices, the ongoing challenges of healthcare affordability, and the slow pace of digital transformation in the industry. We'll explore his views on why many promised healthcare innovations have failed to deliver and what he believes are the most promising solutions on the horizon.

The interview will also touch on sensitive topics that often go undiscussed in mainstream healthcare conversations. Holt may share his unfiltered thoughts on the influence of big pharma and insurance companies, the shortcomings of current health policies, and the real-world consequences of a fragmented healthcare system.

About
Matthew Holt is the founder and publisher of The Health Care Blog and still writes regularly for the site and hosts the #THCBGang and #HealthInTwoPoint00 video shows/podcasts. He was co-founder of the Health 2.0 Conference and now also does advisory work mostly for health tech startups at his consulting firm SMACK.health.

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Previous Episode

Nephro Next: Innovating Kidney Health with Interwell Health CEO, Robert Sepucha

I had the privilege of sitting down with Interwell Health's CEO, Robert Sepucha to explore the future of kidney care in America. The statistics are sobering - chronic kidney disease impacts an estimated 37 million U.S. adults, with over 500,000 relying on dialysis. As I listened to Bobby's insights, it became clear that innovative care models aren't just desirable but crucial. Interwell Health is tackling this challenge head-on, and I was fascinated to learn about its value-based approach. Their mission to improve patient outcomes while simultaneously reducing the enormous $114 billion annual Medicare spending on kidney disease is both ambitious and inspiring.

Our discussion deeply explored what makes Interwell unique. The merger of Fresenius Health Partners, Cricket Health, and Interwell Health has created a powerhouse in kidney care, and I was eager to understand how this combination translates to better patient care. Bobby's explanation of their integrated care model was eye-opening.
By marrying Acumen EHR's sophisticated data analytics with hands-on nephrology expertise, they're reimagining the entire patient care journey. What struck me most was how this approach extends beyond just managing the disease - it's about empowering patients, particularly through increased access to home-based care options

About
As Chief Executive Officer, Bobby leads Interwell Health’s overall strategy and is passionate about helping patients live their best lives while delivering results for payers and providers. Bobby brings over ten years of value-based kidney care experience to his role, having served as CEO of Cricket Health and as a senior executive in policy and corporate affairs at Fresenius Medical Care. He has long worked at the intersection of business, policy, and law, having served as chief of staff to a member of Congress and General Counsel at the Massachusetts Life Sciences Center. He also practiced as an attorney with Gunderson Dettmer in Silicon Valley and Boston where he represented venture capital firms and high-tech startups. Bobby received a Juris Doctor degree from the University of Michigan and a BA degree from Dartmouth College.

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Mitochondria Unlocked: Taking Care Of Your Health at a Cellular Level, Rob Fried, CEO @Chromadex

In this episode I sit down with a good friend and mentor Rob Fried, CEO of ChromaDex, who shares his remarkable transition from Hollywood executive producer to leader of a cutting-edge nutraceutical company. Fried's journey from producing films like Rudy and Godzilla to helming a science-focused organization dedicated to extending human healthspan showcases the power of reinvention and following one's passion.
Through ChromaDex's pioneering research into NAD+ and cellular health, Fried has positioned himself at the intersection of scientific innovation and consumer wellness, bringing Hollywood storytelling skills to communicate complex scientific concepts to a broader audience.
The conversation delves deep into the crucial role of NAD+ in cellular health, particularly its impact on mitochondrial function – our cells' power plants. As Fried explains, our NAD+ levels naturally decline with age, accelerated by modern lifestyle factors like poor sleep, excessive alcohol consumption, and environmental stressors. We explore the growing need for consumer education in the supplement industry and draw compelling parallels between the responsible AI movement and the necessity for ethical governance in the supplement space. Fried advocates for establishing a responsible supplement board to ensure product quality, ingredient sourcing transparency, and consumer safety – addressing the current regulatory gaps in the industry.
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About NAD+
NAD+ (Nicotinamide Adenine Dinucleotide) serves as a fundamental molecule in cellular health, playing multiple vital roles throughout the body. At its core, NAD+ is essential for energy production, working within our mitochondria to convert food into usable cellular energy. Beyond energy production, it acts as a crucial coenzyme for hundreds of biological processes, including DNA repair, gene expression regulation, and cellular stress response. NAD+ activates important proteins called sirtuins, which are often referred to as "longevity genes" due to their role in promoting healthy aging and cellular maintenance. As we age, our natural NAD+ levels decline, potentially contributing to various age-related conditions and decreased cellular function. This decline affects multiple aspects of health, including cognitive function, muscle strength, metabolic health, and cardiovascular wellness. Research has shown that maintaining healthy NAD+ levels can support improved energy levels, enhanced cellular repair, better brain function, stronger immune response, and more efficient metabolism. The molecule's influence extends to supporting liver health, promoting muscle recovery after exercise, regulating circadian rhythms, and potentially protecting against various age-related diseases, making it a crucial target for research in healthy aging and longevity science.
About Rob Fried
Robert Fried is the Chief Executive Officer (CEO) of ChromaDex. Mr. Fried is an Academy Award and Emmy Award-winning motion picture producer. He has held senior roles at entertainment companies Savoy Pictures (CEO), Columbia Pictures (Executive Vice President), and Fried Films (founder, CEO). He has also founded and served as CEO of internet companies Feeln (now Hallmark Movies Now), WHN (a leading e-commerce service provider), and Healthspan Research (now part of ChromaDex). Mr. Fried holds a B.S. from Cornell University and an M.B.A. from the Columbia University Graduate School of Business.

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