Dr. Ben Lynch on Gene Variants that Impact Your Mood, Memory and Gut Health

Dr. Ben Lynch discusses more about histamine, gut health and why gallbladder issues are so common and tips to optimize. We also look at gene testing and why considering clusters of interrelated genes and their associated networks instead of myopically focusing on one good or bad gene variant is much more useful for determining your health weaknesses and strengths.

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Key Takeaways:

06:23 Genetic testing identifies a potential susceptibility to health and mental health complications. It is one of many tools.
06:50 Dirty Genes book is full of quizzes which identifies genetic issues without doing genetic testing.
07:45 Lifestyle habits are passed down through generations, so issues may not be caused by genes.
08:35 Less than 5% of cancers are heritable. Only 1% of Parkinson’s is genetic.
09:25 Conventional medicine using pharmacological interventions are by force. Naturopathic and functional medicine is nurture and restorative, with an appreciation for the biochemical network.
10:50 Look at genes in a wholistic way. There are about 18,000 genes in our bodies.
12:10 A single variant is minuscule compared to the other 18,000 genes communicating. And there are many other variables that make studying a single variant complicated. For example, is the study subject sleeping in a hot or cold room, mouth breathing, has a sleep partner snoring, and loaded with stress? It appears as though epigenetics overrides the majority of other provocations.
13:40 You must look at the research with a wholistic view. Look at many studies.
14:35 You do not need genetic testing. Listen to how your body is feeling and give those areas in need more love, attention, and protection.
16:12 Some genes are highly influenced by epigenetics and others are not. Sometimes is it a matter of workload for the gene.
18:00 If you have the MTHFR variant, you are less likely to die from malaria. You may have a reduced ability to methylate folate, but methylfolate can be found in leafy green vegetables and animal livers.
20:40 At some point, mutated genes helped your ancestors survive. Our genes are adapting to our new environment, and we are passing this on to our kids.
23:20 Dr. Lynch had to choose 7 genes out of 18,000 for the book. He chose MTHFR because it effects the entire genome. Two glutathione genes were chosen because oxidative stress effects the entire genome.
24:00 CMT and MAOA were chosen for their impact upon brain function.
24:30 DAO works on histamine metabolism in the gut, which can cause leaky gut.
25:00 PEMT: Solid cell membranes create cell membranes and create storage for histamine and your neurotransmitters. This phosphatidyl choline synthesizing gene highly polymorphic.
26:45 Nitric oxide is important for emergent heart issues.
26:50 By focusing on supporting these 7 genes, you are positively influencing all of your genes.
28:45 Phosphatidyl choline keeps your bile from being thick and sludgy. You need 10 parts phosphatidyl choline to one part cholesterol to have your bile flow.
30:23 If you are an obese woman in your 40s and still fertile, you will struggle with a gallbladder issue, especially if you have a PEMT variant. The primary stone in the gallbladder is formed from cholesterol. It stems from fatty liver.
32:44 The phosphatidyl choline supplement is used to improve bile flow, but since it is a lipid, it cannot be fully absorbed to improve bile flow. With PEMT variant, reduce consumption of fats and reduce the workload on that gene.
33:45 Visceral manipulation is a near instant fix for bile flow. It is massage to compress your liver. You will have an amazing bowel movement. Support with herbs that stimulate bile flow and production, like glycine, taurine, bitter herbs, ginger, and artichoke. Then supplement with phosphatidyl choline.
36:00 There is data about bile acids and dysfunctional bile acid signatures in the brain and heart.
36:50 Bile has antimicrobial properties. Taking ox bile at meals to help with fat metabolization. Ox bile taken between meals gets into your small intestine to kill off overgrowth bacteria. Maybe take it with a little charcoal. Bacteria release gasses and compounds that cause issue when they die and break open. Binding these is important.
38:28 Acid reflux is bile coming through a leaky pyloric sphincter.
39:10 The StrateGene test for neurotransmitters looks at the reduction, transport, binding to the receptor and the synth...