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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

Sean P. Kane, PharmD; Khyati Patel, PharmD

This podcast is produced by pharmacy faculty to supplement study material and provide relevant drug and professional topics. We're hoping that our real-life clinical pearls and discussions will help you stay up-to-date and improve your pharmacy knowledge.
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Top 10 HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast Episodes

Goodpods has curated a list of the 10 best HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast episode by adding your comments to the episode page.

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 056 - Entering the era of biosimilars!

056 - Entering the era of biosimilars!

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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02/07/17 • 31 min

In this episode, we discuss the new FDA categorizations of biosimilars, the legal implications of biologic/biosimilar prescriptions, and the new "follow-on" approval pathway of Basaglar, a new insulin glargine U-100 product.

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 031 - Therapeutic Drug Monitoring III

031 - Therapeutic Drug Monitoring III

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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09/01/15 • 26 min

In this episode, we discuss the therapeutic drug monitoring and dose adjustments for tacrolimus (Prograf) and lithium.

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 159 - A Breath of Fresh Air: Big Changes to the 2023 GOLD Guidelines for COPD

159 - A Breath of Fresh Air: Big Changes to the 2023 GOLD Guidelines for COPD

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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01/10/23 • 38 min

In this episode, we highlight important changes to the 2023 GOLD Guidelines for COPD. In particular, we discuss a revision to the GOLD group classification system and the preferred initial therapies in patients with COPD.

Key Concepts

  1. The newest GOLD COPD guidelines now recognize three GOLD groups – “A”, “B”, and “E”. Group “E” (formerly groups C and D) are patients with frequent exacerbations (defined as 2 or more in the past 12 months or 1 exacerbation requiring hospitalization).
  2. For group “E” patients, the preferred initial inhaler regimen is a LABA+LAMA. Triple therapy (LABA+LAMA+ICS) can be considered if blood eosinophils are elevated.
  3. “Triple therapy” (LABA+LAMA+ICS) has gained traction based on the IMPACT and ETHOS trials – this regimen reduced exacerbations and mortality compared to LABA+LAMA and LABA+ICS.
  4. With an exploding market of new COPD inhalers, the role of the pharmacist is even more critical to help identify affordable medications and provide patient education for proper inhaler technique.

References

  • Global Strategy for Prevention, Diagnosis, and Management of COPD: 2023 Report. Global Initiative for Chronic Obstructive Lung Disease (GOLD). https://goldcopd.org/2023-gold-report-2/
  • IMPACT study: Lipson DA, Barnhart F, Brealey N, et al. Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. N Engl J Med. 2018;378(18):1671-1680. doi:10.1056/NEJMoa1713901
  • ETHOS study: Rabe KF, Martinez FJ, Ferguson GT, et al. Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD. N Engl J Med. 2020;383(1):35-48. doi:10.1056/NEJMoa1916046
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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 167 - Beyond One-Size-Fits-All: Unraveling the Genetic Tapestry of CYP2D6 Drug Metabolism

167 - Beyond One-Size-Fits-All: Unraveling the Genetic Tapestry of CYP2D6 Drug Metabolism

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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06/27/23 • 35 min

In this episode, we review the science behind genetic differences in humans in the CYP2D6 hepatic enzyme responsible for drug metabolism and how these genetic variants can lead to certain drugs being metabolized far too much or far too little, which can cause drug toxicities or a lack of effectiveness.

Key Concepts

  1. About 20-25% of drugs on the market are metabolized by CYP2D6. Humans have a huge degree of variability in CYP2D6 metabolism ranging from “ultra” metabolizers to “poor” metabolizers.
  2. Drugs that heavily rely on CYP2D6 metabolism are prone to large variability in responses due to these genetic differences. Some drugs rely on metabolic inactivation of CYP2D6 whereas other drugs use the enzyme to become converted to a more active compound.
  3. Codeine and tramadol both heavily rely on CYP2D6 activation to a more potent opioid compound. Patients with excessive CYP2D6 activity will have toxicities (from too much of an active metabolite) whereas patients with low CYP2D6 activity will have little therapeutic effect.
  4. Numerous antidepressants (paroxetine, nearly all tricyclic antidepressants, and venlafaxine) rely on CYP2D6 metabolism. Differences in CYP2D6 metabolism have been shown to either cause toxicity or a lack of effectiveness with these medications.

References

  • Chartrand R, Forte AM, Hoger JD, Kane SP, Kisor DF. Pharmacogenomics and Commonly Prescribed Medications. AdvanCE. October 10, 2022. https://www.advancepharmacist.com/courses/pharmacogenomics-and-commonly-prescribed-medications.
  • Caudle KE, Sangkuhl K, Whirl-Carrillo M, et al. Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group. Clin Transl Sci. 2020;13(1):116-124. doi:10.1111/cts.12692
  • Bousman CA, Stevenson JM, Ramsey LB, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants [published online ahead of print, 2023 Apr 9]. Clin Pharmacol Ther. 2023;10.1002/cpt.2903. doi:10.1002/cpt.2903
  • Crews KR, Monte AA, Huddart R, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021;110(4):888-896. doi:10.1002/cpt.2149
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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 033 - PCSK9 Inhibitors

033 - PCSK9 Inhibitors

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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10/13/15 • 32 min

In this episode, we discuss PCSK9 inhibitors, a new drug class for LDL lowering, with a particular focus on alirocumab (Praluent).

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 183 - The Ultimate Guide to Loop Diuretics: An In-Depth Drug Class Review

183 - The Ultimate Guide to Loop Diuretics: An In-Depth Drug Class Review

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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06/28/24 • 35 min

In this episode, we review the pharmacology, pharmacokinetics, adverse effects, monitoring, medicinal chemistry, and more of loop diuretics.

Key Concepts

  1. Loop diuretics (furosemide, torsemide, bumetanide, ethacrynic acid) are the most potent type of diuretic and are used to relieve edema.
  2. Loop diuretics cause an increased loss of sodium, chloride, potassium, hydrogen, magnesium, and calcium ions into the urine. Excessive loss of these ions manifests as hypokalemia, hypomagnesemia, and metabolic alkalosis.
  3. Loop diuretics have an S-shaped dose response curve – a minimum dose is required for diuresis and a “ceiling” effect occurs at higher doses (leading to more ADRs). Doses should be individualized based on the clinical response of the patient.
  4. Ethacrynic acid is incorrectly used in patients with a “sulfa” allergy. The other loop diuretics contain a sulfa moiety but are safe for use in patients with “sulfa” allergy (e.g. allergy to sulfamethoxazole-trimethoprim).
  5. The TRANSFORM-HF trial strongly suggests that there is no clinical difference between furosemide and torsemide.

References

  • Rachoin JS, Cerceo EA. Four nephrology myths debunked. J Hosp Med. 2011;6(5):E1-E5. doi:10.1002/jhm.703
  • Strom BL, Schinnar R, Apter AJ, et al. Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med. 2003;349(17):1628-1635. doi:10.1056/NEJMoa022963
  • Buggey J, Mentz RJ, Pitt B, et al. A reappraisal of loop diuretic choice in heart failure patients. Am Heart J. 2015;169(3):323-333. doi:10.1016/j.ahj.2014.12.009
  • Mentz RJ, Anstrom KJ, Eisenstein EL, et al. Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial. JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924
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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 100 - Evolution or Revolution? The Future of Pharmacy and Pharmacy Education

100 - Evolution or Revolution? The Future of Pharmacy and Pharmacy Education

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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08/20/19 • 35 min

We are proud to announce our 100th HelixTalk episode! In celebration, we sit down with Dr. Marc Abel, the Dean of the College of Pharmacy at RFUMS to discuss the profession of pharmacy and the future of pharmacy education.

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 036 - Two new agents for schizophrenia

036 - Two new agents for schizophrenia

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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12/15/15 • 33 min

In this episode, we discuss two agents newly approved for schizophrenia -- Rexulti (brexpiprazole) and cariprazine (Vraylar).

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 015 - Cancer Screenings

015 - Cancer Screenings

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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10/21/14 • 61 min

In this episode, we review a wide variety of cancer screening guidelines with a particular focus on the two most controversial screening areas: breast cancer screening with mammography and prostate cancer screening with PSA levels.

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HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast - 178 - Law & Order: Pharmacy Edition. A Concise Review of High-Yield Pharmacy Law Topics for the MPJE

178 - Law & Order: Pharmacy Edition. A Concise Review of High-Yield Pharmacy Law Topics for the MPJE

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast

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02/13/24 • 56 min

In this episode, we speak with Janeen Winnike, the Associate Dean for Student Affairs at Rosalind Franklin and a co-course director for the Pharmacy Law course at the university. We review some of the key points regarding federal and Illinois pharmacy law – a must-listen especially for graduates preparing for their MPJE exam after graduation!

Key Concepts

  1. The FDA (via the Food, Drug, and Cosmetic Act) primarily regulates manufacturers. Most regulation for pharmacies and pharmacists is via the federal Controlled Substances Act and state-based regulations (acts and administrative codes).
  2. An IND (investigational drug application) is required to begin human clinical trials (phase I-III). An NDA (new drug application) is used for the FDA to consider whether a drug should be approved for use in the US.
  3. The Federal Controlled Substances Act outlines which drugs are scheduled I-V. State law can be more restrictive. C-II drugs have special regulations related to prescribing, ordering/distribution, refills, partial fills, etc.
  4. In Illinois, pharmacists, student pharmacists, and pharmacy technicians are permitted to vaccinate patients aged 7 years and older (or temporarily 3 years and older per the PREP act for COVID-19 and influenza vaccines). Pharmacists can order and administer COVID-19 and influenza vaccines; other vaccines require a standing order or a prescription in order prior to administration in a pharmacy.

References

  1. Illinois Pharmacy Practice Act (225 ILCS 85) https://ilga.gov/legislation/ilcs/ilcs3.asp?ActID=1318&ChapterID=24
  2. Illinois Pharmacy Practice Act Administrative Code (Part 1330): https://www.ilga.gov/commission/jcar/admincode/068/06801330sections.html
  3. Illinois Controlled Substances Act (720 ILCS 570) https://ilga.gov/legislation/ilcs/ilcs5.asp?ActID=1941&ChapterID=53
  4. Illinois Controlled Substances Act Administrative Code (Part 3100) https://www.ilga.gov/commission/jcar/admincode/077/07703100sections.html
  5. Pharmacist’s Manual: An Informational Outline of the Controlled Substances Act. Drug Enforcement Administration. https://www.deadiversion.usdoj.gov/GDP/(DEA-DC-046R1)(EO-DEA154R1)_Pharmacist%27s_Manual_DEA.pdf
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FAQ

How many episodes does HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast have?

HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast currently has 199 episodes available.

What topics does HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast cover?

The podcast is about Health & Fitness, Pharmacy, Medicine, Podcasts and Drugs.

What is the most popular episode on HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast?

The episode title '114 - What Else to Lose Beside Weight? Nutritional and Pharmacologic Consequences of Bariatric Surgeries' is the most popular.

What is the average episode length on HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast?

The average episode length on HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast is 35 minutes.

How often are episodes of HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast released?

Episodes of HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast are typically released every 21 days.

When was the first episode of HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast?

The first episode of HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast was released on Mar 5, 2014.

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