Unraveling Timothy Syndrome: the new science of human brain development | Sergiu Pasca

08/01/24 • 30 min

This week on From Our Neurons to Yours, we're talking about using new techniques for growing human brain tissue in the lab to solve a rare neurological disorder.
Host Nicholas Weiler sits down with Sergiu Pasca an innovative Stanford scientist who has developed groundbreaking technologies to grow human brain tissue in the lab, creating "organoids" and "assembloids" that model brain disorders like autism and schizophrenia.

Pasca describes the process of turning patient skin cells into embryo-like stem cells and then into functional brain cells that can live and develop for over two years, and even be transplanted into rat brains to study their growth and development.
It may sound like science fiction, but these techniques represent a major step toward understanding and treating complex neurological conditions such as Timothy syndrome, a rare genetic disorder whose biology Pasca has spent the past 15 years unraveling.

Join us for fascinating glimpse into the future of developmental neuroscience and potential for new therapies for our remarkable self-assembling brains.

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Episode Credits
This episode was produced by Michael Osborne, with production assistance by Morgan Honaker, and hosted by Nicholas Weiler. Art by Aimee Garza.

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08/01/24 • 30 min

From Our Neurons to Yours - Unraveling Timothy Syndrome: the new science of human brain development | Sergiu Pasca

Transcript

Nicholas Weiler:

Welcome back. This is From Our Neurons to Yours from the Wu Tsai Neurosciences Institute at Stanford University. I'm your host, Nicholas Weiler.

I am very excited for today's episode, but bear with me for just a moment while I set this up. We're back this week with another conversation featuring Sergiu Pasca. He's a professor of psychiatry and behavioral sciences at Stanford University. And we talked with him last year about a remarkable set of tec

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