Episode 16- "HALT" the use of TXA in GI bleeds?

07/28/20 • 7 min

This week, we review the "HALT-IT" trial. Will you routinely give your patients TXA (tranexamic acid) in the setting of GI bleeds after reading this study?
References:
Roberts I, Shakur-Still H, Afolabi A, et al. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet. 2020; 395: 1927-36
Shakur H, Roberts I, Fawole B, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017; 389: 2105–16
Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010; 376: 23–32
Disclaimer:
The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

Support the show

Find ER-Rx:
- On Instagram: @ERRxPodcast
- On the website: errxpodcast.com
- On YouTube
Disclaimer:

The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

07/28/20 • 7 min

ER-Rx: An ER + ICU Podcast - Episode 16- "HALT" the use of TXA in GI bleeds?

Transcript

Hello and welcome to Episode 16 of ER-Rx. In this episode, we discuss the long-awaited “HALT-IT,” trial, published in June 2020 in the Lancet.
Acute GI bleeding (GIB) is a common cause of death, with a 10% fatality rate for upper GIB and a 3% mortality for lower GIB. Making things worse, patients who re-bleed after initial stabilization are four times more likely to die. Patients with GIB are oftentimes hemodynamically unstable when they present to the ER, and they are usually managed w

Generate a badge

Get a badge for your website that links back to this episode

Select type & size

Copy