Digital Pathology Podcast

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This is a joint podcast episode where the hosts of "Beyond the Scope" - the official Digital Pathology Association podcast and the host of the "Digital Pathology Podcast" meet to talk about what is going on in our discipline.
Together David Tulman, Giovanni Lujan, and Aleksandra Zuraw cover the current digital pathology topics such as digital pathology guidelines for clinical and non-clinical pathology, digital pathology adoption in clinical pathology settings and pharmaceutical pathology as well as how the pandemic influenced the adoption of digital pathology.
This episode is different than most of our episodes and it is really fun to listen to so stay till the end!
THIS EPISODE'S RESOURCES

YouTube Version of THIS episode is here.

Digital Pathology Podcast episode with David Tulman, Instapath:

AUDIO: https://digitalpathologyplace.com/pod...

VIDEO: https://www.youtube.com/watch?v=wECId...

Podcasts with Chen Sagiv, DeePathology:

Digital pathology Podcast: https://youtu.be/DrEUnkYkN28

Beyond the Scope: https://podcasts.apple.com/no/podcast...

Podcasts with David Clunie, Pixelmed Publishing:

Digital Pathology Podcast: https://digitalpathologyplace.com/pod...

Beyond the Scope: https://podcasts.apple.com/us/podcast...

Pathology Visions 2022 registration page:

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What does the FDA jurisdiction for LDTs mean for the labs? Do they need to worry? How do they need to change the way they operate?
In this episode, I talk with Dr. Thomas Nifong, a clinical pathologist and VP of CDX operations at Acrovan Therapeutics, about the recent FDA ruling on laboratory-developed tests (LDTs) issued on May 6th, 2024. We discuss the implications of considering LDTs as medical devices, requiring regulation, and explore the authority of FDA versus CLIA. The conversation also covers historical contexts, practical implications of regulatory changes, and the roles of organizations like CAP, ACLA, and AMP in legal challenges against the FDA. We dive into the differences in requirements between CLIA and FDA, New York's alternative approval route, and potential impacts on lab operations and compliance. Join us for an insightful conversation filled with essential information for those in the field of molecular pathology.
00:00 Introduction and Special Guest Announcement
00:24 FDA's New Rule on Laboratory Developed Tests (LDTs)
01:58 Recording the Podcast: A Casual Lunch Conversation
03:47 Understanding FDA's Authority Over Medical Devices
08:07 Disputes and Legal Challenges
12:03 Practical Implications and Industry Reactions
12:47 Understanding FDA's Focus: Safety and Efficacy
14:11 The Role of CMS and Medical Necessity
14:48 Congressional Involvement and Legal Authority
16:06 Impact on Labs and Future LDTs
18:33 Quality Systems and Compliance
20:16 Modifications and Software Updates
21:16 Conclusion and Next Steps

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Become a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!

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In this episode, I sit down with Dr. Nina Kottler, Associate Chief Medical Officer of Clinical AI at Radiology Partners, to dive into the evolving role of AI in radiology and how it can shape the future of digital pathology. Dr. Kottler shares her unique journey, expertise, and practical frameworks for implementing AI that enhance patient care and streamline diagnostic workflows.

Episode Highlights and Key Moments:

• [00:00:45] Introduction to Dr. Nina Kottler
  Dr. Kottler discusses her background in applied mathematics, her journey into medicine, and her work at Radiology Partners, where she combines clinical practice with AI innovation.
• [00:04:30] Breaking Down Complex Problems in AI
  Nina explains her approach to tackling large clinical challenges by breaking them down into manageable parts, a method that’s essential for developing and optimizing AI solutions.
• [00:08:15] The Role of Data Orchestration
  We dig into “data orchestration” and how ensuring data is aligned with the right AI model is key to producing accurate and reliable clinical outcomes.
• [00:11:45] Life Cycle of an Exam in Radiology
  Nina takes us through each step in the radiology workflow—from the initial patient consultation to reporting—and highlights how AI can streamline and enhance each phase.
• [00:17:00] Evolution of AI Models in Healthcare
  We explore how AI has evolved, from early CAD systems to today’s multimodal and transformer models, and the exciting possibilities they bring to both radiology and pathology.
• [00:23:20] Addressing the Lag in AI Adoption in Healthcare
  We discuss the challenge of keeping up with AI advancements while balancing patient safety, regulatory standards, and the need for reliability in clinical settings.
• [00:27:50] Frameworks for Reducing Variability and Improving Accuracy
  Nina shares actionable frameworks that Radiology Partners uses to reduce variability and improve diagnostic precision—strategies that pathology can learn from.
• [00:32:40] AI in Workflow Optimization: Where It Has Real Impact
  We discuss specific use cases in clinical workflows that show where AI can bring the greatest value, especially in enhancing patient care through optimized processes.
• [00:36:50] The Power of Multimodal AI and Vision-Language Models
  Combining large language models with computer vision is moving diagnostics closer to comprehensive, AI-driven care—a promising development we explore in depth.
• [00:42:15] The Future of Agents in AI
  We dive into the concept of “agents” in AI and how these systems may soon coordinate multiple models for more complex and precise clinical analyses.
• [00:48:10] Where to Learn More about Dr. Nina Kottler’s Work
  Nina shares where you can catch her upcoming talks and presentations, plus resources for staying updated on the latest in AI for radiology and digital pathology.

If you're a pathologist, radiologist, or healthcare professional curious about AI’s impact on diagnostics, this episode is packed with practical guidance on integrating AI into clinical workflows. Join us as we explore how AI is shaping the future of radiology and pathology!

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Become a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!

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Exploring Foundation Models in Digital Pathology: Insights and Tools
In today's DigiPath Digest we talk about the foundation models in pathology.
reviewing abstracts from two notable papers in Nature.
We discuss the high-level overview of these models, including Hamid Tizhoosh's insights on the vast data requirements for developing effective foundational models.
We also explore tools for literature research, comparing PubMed and Undermind.ai, and examine a useful children's book on artificial intelligence :)
The episode features audience interaction and offers updates on digital pathology trends, along with a personal anecdote on the nature of comparison based on a yoga class experience.
00:00 Introduction and Overview
00:16 Foundation Models in Pathology
00:33 Comparing Research Tools
01:03 Live Stream Interaction
01:12 Starting the Podcast
04:51 Foundation Models Explained
05:11 Research and Findings
06:34 Children's Book on AI
08:00 Deep Dive into Foundation Models
14:28 Case Studies and Examples
18:18 Discussion on Data and Models
21:00 Final Thoughts and Questions
26:24 Exploring ToxPath and Foundation Models
27:05 Introduction to Image Repositories
28:36 Using PubMed for Research
30:35 Exploring Undermined Tool
35:42 Comparing PubMed and Undermined
41:00 Final Thoughts and Recommendations
TODAY'S ABSTRACTS & RESOURCES
📄 Here are the abstracts reviewed today:

• A visual-language foundation model for computational pathology
• A foundation model for clinical-grade computational pathology and rare cancers detection

▶️ Hamid Tizhoosh's lecture:

• "Foundation Models and Information retrieval in Pathology"

🔧 The tool we tried today

• Undermind (for literature research)

📕 A book we discussed :)

• "ABC of Artificial Intelligence. Baby University"

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Become a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!

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How is digital pathology used in clinical trials? Because digital pathology as a discipline began with the aim of streamlining clinical trials, one could assume that this is currently the default.
Unfortunately, this is not the case... In today's discussion, our guest, Dr. Monika Lamba, a pathologist from Q2 Solutions, the lab division of IQVIA, sheds light on how digital pathology revolutionizes the landscape of clinical trials but also where we can still see the gaps.
In this engaging conversation, we discover how the origins of telepathology marked the inception of digital pathology and its journey to becoming an essential component of clinical trials.
Dr. Lamba walks us through the complexities of clinical trials, their organization, and patient matching across multiple sites and international boundaries.
As we unravel the role of pathology in clinical trials, we delve into how eligibility criteria, participant engagement, and informed consent are intricately woven into the process. Dr. Lamba educates us on the critical role of pathology in stratifying and randomizing patients, as well as evaluating outcome measures.
From disease staging to pathologic complete response assessments, pathology guides the way toward precision medicine and targeted therapies. Don't miss this captivating episode where we explore the synergy between digital pathology and clinical trials, paving the path for medical advancements and transformative healthcare solutions. Tune in now to expand your horizons on the ever-evolving intersection of digital pathology and clinical trials.
Start your 7-day free trial: Digital Pathology Club Membership
EPISODES YOU WILL ALSO ENJOY:

• Is this the year of AI in Pathology? And what about ChatGPT? A crossover podcast with "Beyond the Scope"
• What you need to know about Digital Pathology Trends: Takeaways from the DP&AI Global Engage Event w/ Giovanni Lujan, Ohio State University

DIGITAL PATHOLOGY RESOURCES:

• Digital Pathology Club Membership
• Bridging the Gap between Pathology and Computer Science - FREE Online Course
• Digital Pathology Starter Kit

Support the show

Become a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!