Using Data and Omics to predict Dementia Risk & Progression

12/09/22 • 30 min

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Cristina Legido-Quigley, Head of Systems Medicine, at King's College London, Dr Petra Proitsi, ARUK Senior Post-doctoral Research Fellow also from King's College London and Dr Maryam Shoai, Senior Research Fellow in Statistical Genetics at University College London.

Dr Cristina Legido-Quigley - We work with omics sciences, this is mapping thousands of molecules in the body with our technology and then with data science trying to see which are the most important and change in Alzheimer’s. The next step is replenishing these molecules if they are beneficial or monitoring them if they signal a problem or a inflammatory.

Dr Petra Proitsi - I leverage genetic and multi omics (particularly metabolomics) information to enhance early dementia prediction and to find prevention and intervention targets.

Dr Maryam Shoai - I work in the Faculty of Brain Sciences on genetic data to identify predictive models for both risk of disease and progression of disease! This work has previously included exploring Nanotechnology, Materials Chemistry and Statistical Genetics. I have an interest in Big Data, Genetics, and Statistical methods for identification of risk and progression variables in neurodegenerative disorders.

The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

Dr Petra Proitsi - I leverage genetic and multi omics (particularly metabolomics) information to enhance early dementia prediction and to find prevention and intervention targets.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

Previous Episode

Understanding the Biology of Alzheimer's Disease with Neuroscience

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Mark Dallas, Associate Professor in Cellular Neuroscience at University of Reading and Dr Richard Lofthouse, Research Fellow at University of Aberdeen & TauRx.

Dr Mark Dallas - Our research looks at non neuronal cells and the role they play in both initiating and progressing dementia. In particular we are looking at the role of microglia in regulating the inflammatory status of the drive and revealing the balance between good and bad inflammation. This is explored in the lab using a range of techniques looking at the changes in cellular function under disease relevant conditions.

Dr Richard Lofthouse - I am working on Biomarkers for Alzheimer's disease. We are researching tau antibodies and their use in different combinations to determine the fragmentation profile of tau in health and disease.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

Next Episode

Doing clever things with MRI Scans (and other tools) to Beat Dementia

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Riccardo Manca, Research Fellow at Brunel University London, Dr Jodi Watt a Postdoctoral Research Assistant at University of Glasgow and Dr Claire Lancaster, Alzheimer's Society Research Fellow at University of Sussex.

Dr Riccardo Manca - My background is primarily in neuropsychology and neuroimaging analysis. My main research interests and topics I am currently working on are: 1) Structural and functional neuroimaging correlates of neuropsychiatric symptoms in older adults with Alzheimer's disease; 2) neurocognitive decline in older adults from under-represented groups, primarily sexual minorities (project funded by the Alzheimer's Association); 3) non-pharmacological interventions for cognitive decline in multiple sclerosis and dementia; 4) alterations in the dopaminergic system in early AD.

Dr Jodi Watt - I work on a metric called the Brain Health Index, which aims to quantify brain health using various types of structural MRI. Combining different types of MRI allows us to assess different features of neurodegeneration and vascular change, features which tend to co-exist in older populations and certain conditions such as dementia or stroke. Outside of my day-to-day role, I am heavily involved in EDI initiatives within the world of MRI.

Dr Claire Lancaster - I am an Alzheimer's Society Research Fellow investigating the relationship between cognition and brain activity in individuals predisposed to future Alzheimer's Disease. My research uses a combination of behavioural assessment, MRI neuroimaging, pharmacology and cohort analyses. In addition, I work on the Alzheimer's Society GameChanger study and Alzheimer's Research UK Early Detection of Neurodegenerative Disease project - both of which explore the value of remote, digital assessment for the detection of preclinical dementia

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk