Bio Bytes 28: Systems Approaches to Studying Neural Circuitry with Darcy Kelley

03/13/22 • 33 min

In which Darcy Kelley, Harold Weintraub Professor of Biological Sciences, and James discuss Xenopus as a model organism for understanding the biology of behavior and evolution of neural circuits. Professor Kelley describes several ways in which contemporary methods like single-cell RNA sequencing and optogenetics are helping us understand the true connection between neurobiology and behavior. Additionally, she provides insight on how young scientists can effectively develop themselves after initial exposure to research.

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This episode is cross-posted from our new show, Bioworks, which focuses on topics in life science policy, business, entrepreneurship, and investment. Check out other episodes on Bioworks here: https://anchor.fm/bioworks

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Bio Bytes 29: Kinase Proteomics and Oncology with Neil Vasan

In which Neil Vasan, assistant professor of medicine and medical oncologist at the Columbia University Irving Medical Center, and Vaibhav discuss the biochemistry and structural biology of kinases, as well as their salience in cancer development and progression. Neil tells the story behind his critical discovery of hyper-activating double mutations cooccurring in cis on PI3K alleles, discusses his group's use of deep mutational scanning in elucidating mechanisms of drug resistance and disease pathogenesis, and describes his efforts to illuminate the dark phosphoproteome. As well, he discusses how proteomics complements genomic approaches to understanding cancer and provides advice for aspiring physician-scientists.