Extra-Cardiac Clues to Amyloidosis

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a type of systemic amyloidosis in which misfolded transthyretin protein is deposited in the myocardium. Early diagnosis of amyloidosis is necessary to prevent ATTR-CM and its dire consequences. It is increasingly recognized that early signs of amyloidosis may involve protein deposits in other parts of the body causing orthopedic, gastrointestinal, and neurologic pathologies among others. It is critical that clinicians from diverse specialties are knowledgeable regarding the early clues of amyloidosis to prevent the progression to ATTR-CM. This podcast will offer guidance on early identification of non-cardiac manifestations of amyloidosis from the perspective of the Gastrointestinal and Neurology clinical communities.

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