Dr. Hilde Mangold or how to live your life on fast forward

Choosing Science: Stories of Perseverance, Humanity, and Success

04/01/22 • 27 min

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The short but fruitful life of Hilde Mangold produced one of the few doctoral dissertation that has ever been directly linked to a Nobel prize.
Hilde performed transplantations of cells from one darker newt embryo (type of amphibian) into a receiver lighter embryo in order to see if the transplanted cells will trigger the formation of parallel body axis that can be distinguished between them by colour. After hundreds of such delicate and complex transplantations, she managed to obtain such animals, proving the fact that thise specific cells were behind the rearrangement and fate specification of the rest of the cells in the embryo. These cells were coined as the "Spemann-Mangold organizer" after Hilde and her supervisor. These were remarkable findings that changed the trajectory of the modern developmental biology. Eleven years later this discovery was awarded the Nobel prize. Unfortunately, Hilde did not get to see this day coming.
If you want to listen to the whole story of this gifted and determined woman, take a peak!
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1. https://embryo.asu.edu/pages/hilde-mangold-1898-1924

2. https://www.jax.org/news-and-insights/jax-blog/2016/october/women-in-science-hilde-mangold#

3. https://www.nobelprize.org/prizes/medicine/1935/spemann/lecture/

4. Hilde Mangold (1898-1924) and Spemann's organizer: achievement and tragedy

Peter E. Fiissler*, Klaus Sander

Institut ftir Biologie I (Zoologie) der Albert-Ludwigs-Universit~it, Albertstrasse 21 a,

D-79104 Freiburg, Germany

5. Hilde Mangold, Co-Discoverer of the Organizer

VIKTOR HAMBURGER

6. https://veteriankey.com/development-of-important-model-species-ii-vertebrates/

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04/01/22 • 27 min

Choosing Science: Stories of Perseverance, Humanity, and Success - Dr. Hilde Mangold or how to live your life on fast forward

Transcript

The story for today will be short and intense, but not because there isn’t a myriad of things about our subject worth mentioning, but because she unfortunately had an early and tragic passing. She has written one of the few PhD dissertations directly linked to a Nobel prize and has laid groundwork for modern embryology and developmental biology together with another influential biologist of the 20th century. Her name was Hilde Proescholdt, later called Mangold.

She was born in a wealth

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