CCO Oncology Podcast

In this podcast episode, George D. Demetri, MD, and Alexander Drilon, MD, discuss emerging data on the efficacy, safety, and clinical role of second-generation TRK inhibitors that can overcome acquired resistance to first-generation agents in NTRK fusion–positive solid tumors. Topics include:

• Mechanisms of acquired resistance to TRK inhibitor therapy
• Clinical trial data on the second-generation inhibitors selitrectinib and repotrectinib
• Safety profiles of first- vs second-generation TRK inhibitors

Presenters:

George D. Demetri, MD
Professor of Medicine
Harvard Medical School
Harvard University
Co-Director, Ludwig Center at Harvard
Senior Vice President for Experimental Therapeutics
Director, Sarcoma Center
Dana-Farber Cancer Institute
Boston, Massachusetts

Alexander Drilon, MD
Chief, Early Drug Development
Attending, Thoracic
Memorial Sloan Kettering Cancer Center
New York, New York

Link to full program, including downloadable slides:
https://bit.ly/2YFIPfr

In this episode, Kanwal Raghav, MD, and Rachel Riechelmann, MD, PhD, discuss key data supporting contemporary dosing strategies with the later-line treatment options regorafenib and TAS-102 for patients with mCRC, with topics including:

• Individualizing therapy
• Clinical data and experience informing optimal dosing
• Key adverse events

Presenters:

Kanwal Raghav, MD, MBBS
Associate Professor, Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Rachel Riechelmann, MD, PhD
Head, Clinical Oncology Department
Medical Oncologist
AC Camargo Cancer Center
Sao Paulo, Brazil

Content based on an online CME program supported by an educational grant from Bayer HealthCare Pharmaceuticals Inc.

Link to full program:
https://bit.ly/3aVXplL

In this episode, listen to Guy A. Young, MD, as he counsels a teenage patient with severe hemophilia A and the patient’s mother on various available treatment options and strategies for optimizing hemophilia A prophylaxis and adherence. Topics include:

• Overcoming challenges to adherence
• Choice of standard vs extended half-life factor VIII vs emicizumab
• Safety and efficacy data with emicizumab

Presenter:

Guy A. Young, MD
Professor of Pediatrics
Director, Hemostasis and Thrombosis Center
Children’s Hospital Los Angeles
University of Southern California Keck School of Medicine
Los Angeles, California

Link to full program:
https://bit.ly/3FxrVk2

In this episode, George D. Demetri, MD, and Alexander Drilon, MD, discuss the biologic rationale behind testing for NTRK fusions in patients with various solid tumors, along with clinical strategies for testing. Topics include:

• Differences between NTRK fusions vs gene mutations
• Frequency of NTRK fusions by age and tumor type
• When to test patients for NTRK fusions and interpreting reports
• Methods of testing: multiplex gene testing, next-generation sequencing of DNA vs RNA, immunohistochemistry, and liquid biopsy

Presenters:

George D. Demetri, MD
Professor of Medicine
Harvard Medical School
Harvard University
Co-Director, Ludwig Center at Harvard
Senior Vice President for Experimental Therapeutics
Director, Sarcoma Center
Dana-Farber Cancer Institute
Boston, Massachusetts

Alexander Drilon, MD
Chief, Early Drug Development
Attending, Thoracic
Memorial Sloan Kettering Cancer Center
New York, New York

Link to full program:
https://bit.ly/2YFIPfr

Link to slideset based on this podcast:
https://bit.ly/3amgU6w

In this episode, Michael Callaghan, MD; Miguel A. Escobar, MD; and Rebecca Kruse-Jarres, MD, MPH, answer questions from a clinician audience on topics related to hemophilia management including:

• Maintaining long-term musculoskeletal health
• Identifying patients most likely to benefit from pharmacokinetics-guided prophylaxis
• Managing combination therapies in older patients with comorbidities
• Youngest age at which patients can be considered for emicizumab
• Development of resistance to emicizumab
• Switching recombinant factor therapies
• Using bypassing agents with emicizumab for breakthrough bleeds in patients with inhibitors
• Potential clinical role of extending FVIII half-life with BIVV001
• Considerations when dosing emicizumab monthly

Presenters:

Michael Callaghan, MD
Associate Professor
Department of Hematology
Wayne State University
Hematologist
Division of Hematology/Oncology
Children’s Hospital of Michigan
Detroit, Michigan

Miguel A. Escobar, MD
Professor of Medicine and Pediatrics
Department of Hematology
University of Texas Health Science Center
McGovern Medical School
Director
Gulf States Hemophilia and Thrombophilia Center
Houston, Texas

Rebecca Kruse-Jarres, MD, MPH
Professor
Department of Medicine
University of Washington
Executive/Medical Director
Washington Institute for Coagulation
Seattle, Washington

Content supported by educational grants from Genentech, a member of the Roche Group; Sanofi Genzyme Corporation; and Takeda Pharmaceutical Company Ltd.

Link to full program, including downloadable slidesets, expert commentaries, and on-demand Webcast: http://bit.ly/2MW5uhi