CCO Infectious Disease Podcast

In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD​, discusses strategies for and importance of HIV care engagement and reengagement for those who have fallen out of care. Her overview includes:

• WHO Global Health Strategy on HIV
• Longitudinal HIV care trajectories
• Promotion of successful care and antiretroviral therapy (ART) adherence
• Differentiated service delivery
• Improving care and ART adherence in high-risk groups
• Patient perspectives on ART persistence

Presenter:
Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD​
Director​
Desmond Tutu HIV Centre​
Past President​
International AIDS Society​
Faculty of Health Sciences​
University of Cape Town
Cape Town, South Africa​

Panelists:
Nagalingeswaran Kumarasamy, MBBS, FRCP, PhD​
Chief and Director
VHS-Infectious Diseases Medical Centre​
Director
Chennai Antiviral Research and Treatment (CART) Clinical Research Site​
Voluntary Health Services​
Chennai, India

Chloe Orkin, MBChB, FRCP, MD​
Professor of HIV
Queen Mary, University of London​
Consultant Physician​
Lead for HIV Research
Barts Health NHS Trust​
The Royal London Hospital​
London, United Kingdom​

Babafemi Taiwo, MBBS​
Gene Stollerman Professor of Medicine​
Chief, Division of Infectious Diseases​
Northwestern University
Feinberg School of Medicine​
Chicago, Illinois

Content based on an online CME program supported by an independent educational grant from Gilead Sciences.

Follow along with the slides:
https://bit.ly/3dSNoum

Link to full program:
https://bit.ly/3AE2AV1

In this episode, Kyle Molina, PharmD, BCIDP, provides an overview of treatment of skin and soft tissue infections (SSTIs) and challenges in practice. Listen as he gives perspectives on:

• Guideline recommendations for treatment of purulent and nonpurulent SSTIs
• Logistical challenges with IV and oral antibiotics
• Pros and cons of various locations of care
• Data supporting the safety and efficacy of long-acting lipoglycopeptides for treatment of SSTIs
• Use of long-acting lipoglycopeptides in special populations of interest, including patients with obesity, diabetes, and injection drug use
• Overall place in therapy of long-acting lipoglycopeptides for SSTIs

Faculty:

Kyle Molina, PharmD, BCIDP
Infectious Diseases Clinical Pharmacist
Scripps Green Hospital
La Jolla, California
Link to full program:

• CCO: https://bit.ly/3J4mg8h
• ProCE: https://bit.ly/3P0vB4E

In this second of 3 episodes, global HIV experts and advocates discuss how HIV care can better meet the diverse needs of people living with HIV as new treatment strategies emerge and continue to evolve, including:

• How the emergence of long-acting injectable HIV treatment has been a game-changer for many people living with HIV
• Emerging strategies that are expanding the application of long-acting ART to address unmet treatment needs
• Potential for future innovations in ART that are hoped will further address unmet needs and preferences of people living with HIV

Faculty:

Ann Avery, MD
Professor of Medicine
Case Western Reserve University
Division of Infectious Diseases
MetroHealth Medical Center
Cleveland, Ohio

Jennifer Blanchette, PhD
Independent Contractor
Clinical Care Options
Colorado, United States

Isolde Butler, MD, MPH
Chief Medical Officer
CrescentCare
New Orleans, Louisiana

Monica Gandhi, MD, MPH
Professor of Medicine
Division of HIV, Infectious Diseases, and Global Medicine
Director, Center for AIDS Research (CFAR)
Medical Director, Ward 86 HIV Clinic
University of California, San Francisco (UCSF)
San Francisco, California

Marissa Gonzalez
Chair
Community Advisory Board
The Well Project

Angelina Namiba
Founder Member
4M Network of Mentor Mothers
London, United Kingdom

Chloe Orkin, MBChB, FRCP, MD
Professor of Infection and Inequities
Faculty of Medicine and Dentistry
Queen Mary University of London
Blizard Institute
Barts Health NHS Trust
London, United Kingdom

Link to full program:
https://bit.ly/3QFwv7n

Links to programs discussed in the episode:
www.4mmm.org

During the 2023 American Association for the Study of Liver Diseases conference, exciting and important results from many primary biliary cholangitis (PBC) clinical trials were reported, including 3 late-breaking studies on the PPAR-δ agonist seladelpar, the dual PPAR agonist elafibranor, and the combination of the FXR agonist obeticholic acid and a fibrate.

In this episode, Kris V. Kowdley MD, FAASLD, FACP, FACG, discusses topline results from several of these studies and more, including:

• A combination of 3 studies—HEROES, COBALT, and COBALT EC—that evaluated the real-world effectiveness and safety of second-line therapy in PBC where OCA was added to the treatment regimen of people with PBC with an incomplete response to ursodeoxycholic acid
• Lessons learned from a long-term outcomes study of people with PBC
• Results from 2 phase II studies of obeticholic acid plus bezafibrate in people with PBC who did not respond to or were intolerant of ursodeoxycholic acid

Presenter:

Kris V. Kowdley MD, FAASLD, FACP, FACG
Professor, Elson S. Floyd College of Medicine
Washington State University
Director, Liver Institute Northwest
Seattle, Washington

Link to reviews of other PBC studies from AASLD 2023:
https://bit.ly/3RvXXEI

In this episode, global PrEP experts and advocates discuss how current PrEP regimens represent a revolutionary step forward in enabling many individuals to avoid HIV acquisition, including:

• How PrEP has empowered people to take control of their sexual lives, revolutionized people’s sexual experiences, and, for some, improved their experiences with healthcare in general
• The extraordinary progress that has been made in New South Wales and specifically in inner Sydney toward HIV transmission elimination and the role of PrEP in the prevention of new HIV infections
• The importance of having PrEP options, including on-demand options and long-acting formulations, available to different populations who could benefit to see progress toward HIV transmission elimination globally

Faculty:

Jessica L. Adams, PharmD, AAHIVE
Scientific Director, Infectious Diseases
Clinical Care Options
New York, United States

Linda-Gail Bekker, MBChB, DCH, DTM&H, FCP(SA), PhD
Professor and Director
The Desmond Tutu HIV Centre
University of Cape Town
South Africa
Chief Executive Officer
The Desmond Tutu Health Foundation
Cape Town, South Africa

Kenyon R. Farrow
PrEP Advocate
Vice President of Policy
Point Source Youth
Contributing Editor
TheBody.com
Ohio, United States

Beatriz Grinsztejn, MD, PhD
Director
STI/AIDS Clinical Research Laboratory
Instituto Nacional de Infectologia Evandro Chagas-Fiocruz
Rio de Janeiro, Brazil

Andrew Grulich, MBBS, PhD
Scientia Professor
Head, HIV Epidemiology and Prevention Program
The Kirby Institute
University of New South Wales, Sydney
New South Wales, Australia

Jean-Michel Molina, MD, PhD
Professor of Infectious Diseases
University of Paris Cité
Head of the Department of Infectious Diseases
Hospital Saint-Louis and Lariboisière
Paris, France

Brittany Williams, PhD
PrEP Advocate
Assistant Professor of Higher Education and Student Affairs Administration
Department of Education
University of Vermont
Vermont, United States

Link to full program:
https://bit.ly/3FbPBey