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Cancer

Oxford University

Cancer is studied from several angles at NDM, from its epidemiology and potential causes, to its effect on patient lives and outcomes, as well as the basic science underpinning the unregulated cell growth that is the hallmark of the disease. Our Cancer podcasts illustrate the diversity of this research, and provide snapshots to the work of NDM scientists and clinicians to understand, treat and prevent cancer.

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Top 10 Cancer Episodes

Best episodes ranked by Goodpods Users most listened

Melanoma

Cancer

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10/05/15 • 7 min

Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. DEREGULATION OF TRANSCRIPTION The interface between signal transduction and transcription regulation coordinates gene expression. Deregulation of transcription is a key factor in cancer. Professor Colin Goding studies how a precise programme of transcription regulation is achieved, particularly in the transition between normal and cancer stem cells, and the parallels with normal stem cell populations.
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10/05/15 • 7 min

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Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors. EPIGENETIC SIGNALLING Professor Panagis Filippakopoulos is interested in the molecular mechanisms of transcription, where the formation of non-covalent protein complexes is mediated by post-translational modifications. Dysfunction in this epigenetic signalling process is linked to disease, particularly cancer.
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10/05/15 • 4 min

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03/11/15 • 5 min

Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single nucleotide polymorphisms There is great heterogeneity between individuals in their risk of developing cancer, disease progression and responses to therapy. Specific single nucleotide polymorphisms (SNPs) are associated with human cancers. They have the potential to help us identify individuals more at risk of developing cancer, and better target preventative or therapeutic strategies.
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03/11/15 • 5 min

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02/09/15 • 4 min

Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions. Clinical diagnoses can be broad descriptions, but today's test results can help better understand the condition as well as target treatment. Cancer is a good example in which personalised medicine can help decide which molecular targeted therapy is most appropriate.
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02/09/15 • 4 min

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02/09/15 • 3 min

Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments. Ian Tomlinson, Professor of Molecular and Population Genetics at the Wellcome Trust for Human Genetics, works on the identification of genes that predispose to colorectal and other cancers. His research focuses on the relative importance of selection and genomic instability.
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02/09/15 • 3 min

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02/09/15 • 6 min

Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Dr Benjamin Schuster-Böckler heads the computational group at the Ludwig Institute for Cancer Research. His work has demonstrated that epigenetic modifications influence the mutational landscape in cancer cells. He studies the effects of DNA-binding proteins on transcription factors, with the aim to understand the regulation (and mis-regulation) of the transcription of important oncogenes and tumour suppressors.
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02/09/15 • 6 min

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08/30/11 • 5 min

Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Due to advances in medicine prolonging the lives of those with progressive, life limiting diseases, the need for long-term palliative care has increased. Dr Bee Wee is currently researching end of life care for people with incurable cancer and advanced non-malignant disease, symptom management and rehabilitation, to improve quality of life for patients. Dr Wee is the Head of Palliative Care Research and Development, based at Sir Michael Sobell House in Oxford.
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08/30/11 • 5 min

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03/22/13 • 4 min

Professor Xin Lu talks about the links between cancer and regenerative medicine. Identifying the switches that turn cell growth off and on would have profound implications for cancer medicine. If the right mechanisms can be found, cancer cells could be targeted specifically, resulting in more efficient treatments. Professor Xin Lu is working to identify the molecular mechanisms that naturally suppress tumour growth. Nuclear reprogramming could also enable cells to be utilized more safely and effectively in regenerative medicine.
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03/22/13 • 4 min

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07/06/11 • 5 min

Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Cells communicate through receptors on their surface; however, when these finely tuned systems don't work correctly, diseases can be triggered. Professor Yvonne Jones has been working to identify the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer. Professor Jones is director of the Cancer Research UK Receptor Structure Research Group.
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07/06/11 • 5 min

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07/10/12 • 4 min

Dr Patrick Pollard tells us about his research on cancer metabolism. Cancer cells produce energy predominately through a high rate of glycolysis; it has been suggested that this change in metabolism is the fundamental cause of cancer. Dr Patrick Pollard aims to elucidate the alternative metabolic strategies used by cancer cells with high concentrations of glucose to proliferate, even under conditions of stress. These mechanisms could then become targets for more effective cancer therapies.
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07/10/12 • 4 min

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FAQ

How many episodes does Cancer have?

Cancer currently has 16 episodes available.

What topics does Cancer cover?

The podcast is about Health & Fitness, Medicine, Podcasts and Education.

What is the most popular episode on Cancer?

The episode title 'Melanoma' is the most popular.

What is the average episode length on Cancer?

The average episode length on Cancer is 5 minutes.

How often are episodes of Cancer released?

Episodes of Cancer are typically released every 42 days, 1 hour.

When was the first episode of Cancer?

The first episode of Cancer was released on Apr 26, 2011.

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