Log in

goodpods headphones icon

To access all our features

Open the Goodpods app
Close icon
Blood & Cancer - Studying cancer patients with COVID-19: Dr. Brian Rini describes the NCCAPS and CCC19 studies and reviews the latest findings

Studying cancer patients with COVID-19: Dr. Brian Rini describes the NCCAPS and CCC19 studies and reviews the latest findings

09/24/20 • 23 min

Blood & Cancer

How do patients fare when they have cancer and COVID-19? Researchers developed the COVID-19 and Cancer Consortium (CCC19) and the National Cancer Institute COVID-19 in Cancer Patients Study (NCCAPS) to gain some insight.

In this episode, Brian Rini, MD, a professor of medicine at Vanderbilt University Medical Center, Nashville, Tenn., and host of The Uromigos podcast, explains what CCC19 and NCCAPS are. He also discusses findings from CCC19 that were presented at the European Society of Medical Oncology Virtual Congress 2020.

NCCAPS (NCT04387656)

  • NCCAPS is a natural history study of COVID-19 in patients with active cancer.
  • It is a prospective study, funded by the National Cancer Institute, that is open at more than 500 centers.
  • The study is open to U.S. adults who are receiving active cancer treatment and either have COVID-19 or are awaiting a SARS-CoV-2 test result.
  • Researchers collect blood samples and other data from patients enrolled.
    • Blood is collected at baseline and at regular intervals incorporated into patients’ normal oncology follow-up.
    • The samples will be used to assess things like genomics, cytokine abnormalities, and coagulation parameters.
  • No data from NCCAPS have been released to date, but more than 100 patients have been enrolled.
  • For more information, visit the NCCAPS webpage: https://bit.ly/3ck8nBb.

CCC19 (NCT04354701)

  • CCC19 is a retrospective database that includes information on patients with active cancer or a history of cancer who have been diagnosed with COVID-19, with or without a confirmatory test.
  • Health care providers or their proxies from the United States, European Union, Argentina, Canada, Mexico, and United Kingdom can report cases through the CCC19 website.
  • All data are deidentified.
  • More than 100 institutions are now part of CCC19.
  • Data from CCC19 were presented in two abstracts at ESMO 2020:
  • The data from LBA72, which includes nearly 4,000 patients, suggest cancer-specific factors are associated with a greater risk of 30-day all-cause mortality, including:
    • Progressive cancer (adjusted odds ratio, 2.9).
    • Hematologic malignancy (aOR, 1.7).
    • Receiving cancer therapy within the past 3 months (aOR, 1.2).
  • It still isn’t clear if certain cancer treatments increase the risk of mortality, Dr. Rini said, but researchers are investigating that.
  • For more information on CCC19, visit https://ccc19.org/.

Disclosures:

Dr. Rini and Dr. Henry have no relevant conflicts of interest.

* *

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgehemonc

David Henry on Twitter: @davidhenrymd

plus icon
bookmark

How do patients fare when they have cancer and COVID-19? Researchers developed the COVID-19 and Cancer Consortium (CCC19) and the National Cancer Institute COVID-19 in Cancer Patients Study (NCCAPS) to gain some insight.

In this episode, Brian Rini, MD, a professor of medicine at Vanderbilt University Medical Center, Nashville, Tenn., and host of The Uromigos podcast, explains what CCC19 and NCCAPS are. He also discusses findings from CCC19 that were presented at the European Society of Medical Oncology Virtual Congress 2020.

NCCAPS (NCT04387656)

  • NCCAPS is a natural history study of COVID-19 in patients with active cancer.
  • It is a prospective study, funded by the National Cancer Institute, that is open at more than 500 centers.
  • The study is open to U.S. adults who are receiving active cancer treatment and either have COVID-19 or are awaiting a SARS-CoV-2 test result.
  • Researchers collect blood samples and other data from patients enrolled.
    • Blood is collected at baseline and at regular intervals incorporated into patients’ normal oncology follow-up.
    • The samples will be used to assess things like genomics, cytokine abnormalities, and coagulation parameters.
  • No data from NCCAPS have been released to date, but more than 100 patients have been enrolled.
  • For more information, visit the NCCAPS webpage: https://bit.ly/3ck8nBb.

CCC19 (NCT04354701)

  • CCC19 is a retrospective database that includes information on patients with active cancer or a history of cancer who have been diagnosed with COVID-19, with or without a confirmatory test.
  • Health care providers or their proxies from the United States, European Union, Argentina, Canada, Mexico, and United Kingdom can report cases through the CCC19 website.
  • All data are deidentified.
  • More than 100 institutions are now part of CCC19.
  • Data from CCC19 were presented in two abstracts at ESMO 2020:
  • The data from LBA72, which includes nearly 4,000 patients, suggest cancer-specific factors are associated with a greater risk of 30-day all-cause mortality, including:
    • Progressive cancer (adjusted odds ratio, 2.9).
    • Hematologic malignancy (aOR, 1.7).
    • Receiving cancer therapy within the past 3 months (aOR, 1.2).
  • It still isn’t clear if certain cancer treatments increase the risk of mortality, Dr. Rini said, but researchers are investigating that.
  • For more information on CCC19, visit https://ccc19.org/.

Disclosures:

Dr. Rini and Dr. Henry have no relevant conflicts of interest.

* *

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgehemonc

David Henry on Twitter: @davidhenrymd

Previous Episode

undefined - Waist size and prostate cancer death, AI is on par with radiologists for mammograms, and "How I Treat" MDS from ASH Hematologic Malignancies

Waist size and prostate cancer death, AI is on par with radiologists for mammograms, and "How I Treat" MDS from ASH Hematologic Malignancies

This week in Hematology and Oncology news:

  1. Large waistline linked to higher risk of prostate cancer death (https://bit.ly/3iRxmya)
  2. FOLFOXRI tops doublets as bevacizumab backbone for mCRC (https://bit.ly/32QpTKi)
  3. AI algorithm on par with radiologists as mammogram reader (https://bit.ly/35WnAXV)
  4. How I Treat: For low-risk MDS, treat 'what bugs patients most' (https://bit.ly/2ZU5TEU)

* *

Find more Blood & Cancer at https://www.mdedge.com/podcasts/blood-cancer

Email the show at [email protected]

Next Episode

undefined - Hem-Onc News: No benefit from postop radiotherapy in NSCLC, sotorasib is a 'triumph of drug discovery,' and choosing a TKI for ALL

Hem-Onc News: No benefit from postop radiotherapy in NSCLC, sotorasib is a 'triumph of drug discovery,' and choosing a TKI for ALL

Hematology-Oncology News:

  1. No benefit with postoperative radiotherapy in stage IIIA2 NSCLC (https://bit.ly/3i1196r)
  2. First-in-class ADC ups survival in mTNBC (https://bit.ly/2GaoVQ2)
  3. Sotorasib is a 'triumph of drug discovery' in cancer (https://bit.ly/2FQwpIt)
  4. TKI choice key for fit/unfit patients with Ph+ALL (https://bit.ly/3kLdmOs)

Email Blood & Cancer at [email protected]

Episode Comments

Generate a badge

Get a badge for your website that links back to this episode

Select type & size
Open dropdown icon
share badge image

<a href="https://goodpods.com/podcasts/blood-and-cancer-197219/studying-cancer-patients-with-covid-19-dr-brian-rini-describes-the-ncc-19337309"> <img src="https://storage.googleapis.com/goodpods-images-bucket/badges/generic-badge-1.svg" alt="listen to studying cancer patients with covid-19: dr. brian rini describes the nccaps and ccc19 studies and reviews the latest findings on goodpods" style="width: 225px" /> </a>

Copy