
The New Science of Aging
04/22/20 • 47 min
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We have long assumed aging is inevitable, but is it? Professor David Sinclair, founder of the Sinclair Lab at Harvard’s Medical School and author of the bestselling “Lifespan: Why We Age — and Why We Don’t Have To,” joins Azeem Azhar to discuss emerging research that promises to radically slow down aging.
Their conversation covers:
- What the Information Theory of Aging is and how it shifts the paradigm on biomarkers of aging.
- Why periodically stressing your body can promote health and longevity.
- Which supplements might arrest the three biochemical pathways implicated in aging.
Further reading:
- “Why We Age and Why We Don’t Have To” (Talks at Google, 2019)
- “This is why we need to start treating ageing as a disease” (Wired, 2018)
- “Has Harvard’s David Sinclair Found the Fountain of Youth?” (Boston Magazine, 2017)
We have long assumed aging is inevitable, but is it? Professor David Sinclair, founder of the Sinclair Lab at Harvard’s Medical School and author of the bestselling “Lifespan: Why We Age — and Why We Don’t Have To,” joins Azeem Azhar to discuss emerging research that promises to radically slow down aging.
Their conversation covers:
- What the Information Theory of Aging is and how it shifts the paradigm on biomarkers of aging.
- Why periodically stressing your body can promote health and longevity.
- Which supplements might arrest the three biochemical pathways implicated in aging.
Further reading:
- “Why We Age and Why We Don’t Have To” (Talks at Google, 2019)
- “This is why we need to start treating ageing as a disease” (Wired, 2018)
- “Has Harvard’s David Sinclair Found the Fountain of Youth?” (Boston Magazine, 2017)
Previous Episode

Navigating Covid-19 in a Digital Republic (with President of Estonia Kersti Kaljulaid)
In Estonia, the only public service not available online is marriage. Dubbed the “digital republic”, Estonia has the most advanced e-government in the world and nurtures a vibrant start-up community. Kersti Kaljulaid, President of Estonia, joins Azeem Azhar to explore how legal and technological innovations have helped to build e-Estonia, and how this digital republic is navigating the Covid-19 pandemic.
They explore:
- How Covid-19 could accelerate technology development and implementation.
- How Estonia has achieved astonishing transparency and privacy in digital government.
- How Estonia combats constant cyber threats.
Further reading:
- “Estonia, the Digital Republic” (New Yorker, 2017)
- “Why Estonia Was Poised to Handle How a Pandemic Would Change Everything” (New Yorker, 2020)
- “Can AI Be a Fair Judge in Court? Estonia Thinks So” (Wired, 2019)
- The Official Website for E-Estonia
Next Episode

Lessons for an Aging World
For the first time in history, there are more people on the planet over 65 years old, than under five. How do we adapt to this demographic transformation? Camilla Cavendish, award-winning journalist and former Director of Public Policy for UK Prime Minister David Cameron, joins Azeem Azhar to explore the immense cost and new potential of this brave old world.
They discuss:
- The huge wealth gap opening up between older and younger people.
- What we can learn from the Okinawan concept of “ikigai” or “life purpose”.
- Why meaningful relationships are the single most important factor in long-term wellbeing.
Further reading:
- “The New Science of Aging” (Exponential View podcast, 2020)
- “Extra Time: 10 Lessons for An Ageing World Camilla Cavendish” (2019)
- “We are prioritising the old and will have to make it up to the young” (Financial Times, 2020)
- “The Three Cleavages” (Azeem Azhar, 2020)
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