March 2022: Genetics and Brain Transcriptomics of Completed Suicide

Dr. Giovanna Punzi and Dr. Daniel Weinberger (Lieber Institute for Brain Development, Baltimore, Maryland) discuss findings from their new paper, “Genetics and Brain Transcriptomics of Completed Suicide,” which looks at differences in the brains of those who die by violent versus less violent means of suicide. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together.

• Punzi and Weinberger interview [00:43]
• What made the two categories distinct? [02:28]
• Aggression as a factor [03:43]
• Differences in genetic factors [04:58]
• Potential heterogeneity of suicide [06:28]
• Counterintuitive conclusions [07:42]
• Clinical implications for those at risk for suicide [11:00]
• Next steps for research [11:43]
• Kalin interview [12:56]
• McMahon [13:58]
• Jacquemont et al. [14:22]
• Mancini et al. [15:53]
• Mahjani et al. [18:40]
• Leckman [21:22]
• Punzi et al. [21:48]
• Ecker et al. [25:38]
• Summary [28:45]

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