March 2022: Genetics and Brain Transcriptomics of Completed Suicide

03/03/22 • 30 min

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Dr. Giovanna Punzi and Dr. Daniel Weinberger (Lieber Institute for Brain Development, Baltimore, Maryland) discuss findings from their new paper, “Genetics and Brain Transcriptomics of Completed Suicide,” which looks at differences in the brains of those who die by violent versus less violent means of suicide. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together.

Punzi and Weinberger interview [00:43]
What made the two categories distinct? [02:28]
Aggression as a factor [03:43]
Differences in genetic factors [04:58]
Potential heterogeneity of suicide [06:28]
Counterintuitive conclusions [07:42]
Clinical implications for those at risk for suicide [11:00]
Next steps for research [11:43]
Kalin interview [12:56]
McMahon [13:58]
Jacquemont et al. [14:22]
Mancini et al. [15:53]
Mahjani et al. [18:40]
Leckman [21:22]
Punzi et al. [21:48]
Ecker et al. [25:38]
Summary [28:45]

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Punzi and Weinberger interview [00:43]
What made the two categories distinct? [02:28]
Aggression as a factor [03:43]
Differences in genetic factors [04:58]
Potential heterogeneity of suicide [06:28]
Counterintuitive conclusions [07:42]
Clinical implications for those at risk for suicide [11:00]
Next steps for research [11:43]
Kalin interview [12:56]
McMahon [13:58]
Jacquemont et al. [14:22]
Mancini et al. [15:53]
Mahjani et al. [18:40]
Leckman [21:22]
Punzi et al. [21:48]
Ecker et al. [25:38]
Summary [28:45]

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it.

Subscribe to the podcast here.

Listen to other podcasts produced by the American Psychiatric Association.

Browse articles online.

How authors may submit their work.

Follow the journals of APA Publishing on Twitter.

E-mail us at [email protected]

Previous Episode

February 2022: Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD

Dr. Margaret Sibley (University of Washington, Seattle, WA) joins the podcast this month to discuss an article from the February issue of the Journal looking at patterns of remission in attention deficit hyperactivity disorder in children. Dr. Ned Kalin, Editor-in-Chief of AJP will join us afterwards to discuss the rest of the February issue of the Journal.

Sibley interview [00:51]
What does “full remission” from ADHD mean? [01:54]
Variable patterns of remission in children with ADHD [02:33]
The DSM definition of ADHD and the impact of ADHD symptoms [04:10]
Advantages and disadvantages of using longitudinal data [06:50]
What does the pattern of intermittent remission mean for treatment of ADHD? [09:39]
What does this suggest for further research into ADHD diagnosis and treatment? [11:08]
How does this affect treatment going forward? [12:48]
Kalin interview [15:25]
Flavin et al. [16:04]
Sibley et al. [16:45]
Markowitz et al. [18:20]
Tadmon and Olfson [19:07]
Manfredi et al. [20:30]
Morgan et al. [22:39]
Cole et al. [24:57]
In conclusion [29:03]

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it.

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E-mail us at [email protected]

Next Episode

undefined - April 2022: Effects of County-Level Opioid Dispensing Rates on Individual-Level Patterns of Prescription Opioid and Heroin Consumption: Evidence From National U.S. Data

April 2022: Effects of County-Level Opioid Dispensing Rates on Individual-Level Patterns of Prescription Opioid and Heroin Consumption: Evidence From National U.S. Data

Dr. Brian Kelly (Purdue University, West Lafayette, Indiana) discusses a study that found recent efforts to curb opioid prescriptions appear to have had an effect on reducing prescription opioid misuse and dependence, with no evidence that shifts in local-level opioid dispensing affected odds of heroin use, frequency of heroin use, or heroin dependence. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together.

Kelly interview [00:30]
Why county level data? [01:22]
What accounts for the variation between counties? [02:28]
Decreased prescription rates did not lead to increased heroin usage [04:07]
How do we ensure the needs of those who need pain management? [04:55]
What should happen with opioid dispensing practices? [06:10]
National Survey on Drug Use and Health [07:30]
Next steps [08:35]
Kalin interview [09:34]
Vuolo and Kelly [09:58]
Watts et al. [11:25]
O’Keeffe et al. [14:25]
Sohal [17:35]
Chung et al. [18:35]
Summary [23:05]

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it.

Subscribe to the podcast here.

Listen to other podcasts produced by the American Psychiatric Association.

Browse articles online.

How authors may submit their work.

Follow the journals of APA Publishing on Twitter.

E-mail us at [email protected]