
Gaming Is Among Us
10/25/20 • 15 min
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Aliens are among us. Well, the online multiplayer game Among Us is -- a murder mystery set in space, where the group must figure out who the alien imposter is (a variation of party games like Werewolf or Mafia) -- has seemingly suddenly become very popular. And not just because a major politician livestream-played it earlier this week, which is what makes this news.
So on this episode of 16 Minutes on the News -- our show where we talk about what's in the headlines; tease apart what's hype/ what's real; and where we are on the long arc of innovation with related tech trends -- we cover:
- Who, how, and why now? Especially since the game, from indie game company InnerSloth, has been around since 2018 -- what if it's NOT just "the pandemic effect" (where people are seeking new ways to connect);
- What are the underlying trends involved -- from social to streaming -- but digging in on the twists, and nuances, of both;
- What are the implications for startups and big companies when it comes to the gaming market, beyond this game?
All this and more, in less than 16 minutes, with a16z consumer team partner Jonathan Lai (formerly at Tencent games, Riot Games) in conversation with host Sonal Chokshi.
headlines & sources for stats/quotes cited in this episode:
- "Everything to know about the game everyone is obsessing over", CNET [stats, roadmap]
- "Everyone's playing Among Us", New York Times [quote from Kotaku's Nathan Grayson]
Aliens are among us. Well, the online multiplayer game Among Us is -- a murder mystery set in space, where the group must figure out who the alien imposter is (a variation of party games like Werewolf or Mafia) -- has seemingly suddenly become very popular. And not just because a major politician livestream-played it earlier this week, which is what makes this news.
So on this episode of 16 Minutes on the News -- our show where we talk about what's in the headlines; tease apart what's hype/ what's real; and where we are on the long arc of innovation with related tech trends -- we cover:
- Who, how, and why now? Especially since the game, from indie game company InnerSloth, has been around since 2018 -- what if it's NOT just "the pandemic effect" (where people are seeking new ways to connect);
- What are the underlying trends involved -- from social to streaming -- but digging in on the twists, and nuances, of both;
- What are the implications for startups and big companies when it comes to the gaming market, beyond this game?
All this and more, in less than 16 minutes, with a16z consumer team partner Jonathan Lai (formerly at Tencent games, Riot Games) in conversation with host Sonal Chokshi.
headlines & sources for stats/quotes cited in this episode:
- "Everything to know about the game everyone is obsessing over", CNET [stats, roadmap]
- "Everyone's playing Among Us", New York Times [quote from Kotaku's Nathan Grayson]
Previous Episode

A Nobel for CRISPR! When, Who, How, What Now
"It's CRISPR!" This week, the Nobel Prize in Chemistry was awarded to scientists Emmanuelle Charpentier and Jennifer Doudna (also an a16z co-founder, of Scribe Therapeutics), for the development of the CRISPR/Cas9 method for genome editing -- a technology that's "had a revolutionary impact on the life sciences, is contributing to new cancer therapies, and may make the dream of curing inherited diseases come true".
While many describe this technology as "genetic scissors", one of the sharpest tools, is that analogy too limited for describing the true power and potential of CRISPR as a gene-editing platform? And while the time between (unexpected) discovery to practice to award has been less than a decade -- further confirming that we're in the new century of biology! -- at what point does such discovery become engineering, that is, innovations we can use and systematize and scale (much like transistors)?
In this special episode of 16 Minutes, a16z general partners Vijay Pande and Jorge Conde, in conversation with Sonal Chokshi, examine the long arc and narrative of CRISPR, both backwards and forward; tease apart what's hype/ what's real in terms of where we really are, in practice; and... celebrate the incredible milestone this is. It's CRISPR!, and much more...
articles cited in this episode [see also related pieces below]
"Pioneers of revolutionary CRISPR gene editing win chemistry Nobel", Heidi Ledford & Ewen Callaway, Nature, 7 October 2020
"The Nobel Prize in Chemistry 2020", The Royal Swedish Academy of Sciences, NobelPrize.org, 7 October 2020
image: Bianca Fioretti / Wikimedia Commons
Next Episode

Covid Vaccine! Beyond Science via Press Release
A vaccine for COVID seems to be (almost) here... or is it? What's hype/ what's real beyond the headlines (and beyond the press release), when it comes to the announcement earlier this week from Pfizer and BioNTech that their vaccine candidate was found to be more than 90% effective in preventing COVID-19? Of course, this was just the first interim efficacy analysis -- so how close or far are we? What's the significance of the readout and case numbers? How do we put this (and related approaches, like Moderna's) in context of all the other (458!) programs in development? And how much should/ shouldn't we read into this news?
After all, it's "difficult to evaluate science via press release", as some say. So in this episode of 16 Minutes with a16z bio general partners Vineeta Agarwala and Jorge Conde in conversation with Sonal Chokshi, we break it all down: the math, the science, and the practical considerations -- from "vaccine efficacy" vs. efficiency, from cold chains to distribution, from patients to the system... as well as from the past, to present future of, vaccines.
references and readings cited in this episode:
- BioCentury.com/coronavirus, COVID-19 therapies and vaccines: Clinical; COVID-19 therapies and vaccines: Preclinical; COVID-19 Clinical Trial Dashboard, November 2020
- "Vaccine Efficacy 101: A biostatistician's primer", Natalie E. Dean, Twitter, September 2020
- "Understanding COVID-19 vaccine efficacy", Marc Lipsitch and Natalie E. Dean, Science, November 2020
- "Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate", Matthew Herper (with Helen Branswell), STAT, November 2020
- "A Framework for Equitable Allocation of Vaccine for the Novel Coronavirus", National Academies of Sciences, Engineering, and Medicine, October 2020 [report highlights pdf] [full report web preview]
- "I was part of a trial for Pfizer’s Covid-19 vaccine. It’s a miracle for genetic medicine.", Walter Isaacson, Washington Post, November 2020
- "On Vaccines and Vaccinology, in COVID and Beyond", with Rajeev Venkayya & Jorge Conde, a16z Podcast, August 2020
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