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16 Minutes News by a16z - A Nobel for CRISPR! When, Who, How, What Now

A Nobel for CRISPR! When, Who, How, What Now

10/10/20 • 23 min

16 Minutes News by a16z

"It's CRISPR!" This week, the Nobel Prize in Chemistry was awarded to scientists Emmanuelle Charpentier and Jennifer Doudna (also an a16z co-founder, of Scribe Therapeutics), for the development of the CRISPR/Cas9 method for genome editing -- a technology that's "had a revolutionary impact on the life sciences, is contributing to new cancer therapies, and may make the dream of curing inherited diseases come true".

While many describe this technology as "genetic scissors", one of the sharpest tools, is that analogy too limited for describing the true power and potential of CRISPR as a gene-editing platform? And while the time between (unexpected) discovery to practice to award has been less than a decade -- further confirming that we're in the new century of biology! -- at what point does such discovery become engineering, that is, innovations we can use and systematize and scale (much like transistors)?

In this special episode of 16 Minutes, a16z general partners Vijay Pande and Jorge Conde, in conversation with Sonal Chokshi, examine the long arc and narrative of CRISPR, both backwards and forward; tease apart what's hype/ what's real in terms of where we really are, in practice; and... celebrate the incredible milestone this is. It's CRISPR!, and much more...

articles cited in this episode [see also related pieces below]

"Pioneers of revolutionary CRISPR gene editing win chemistry Nobel", Heidi Ledford & Ewen Callaway, Nature, 7 October 2020

"The Nobel Prize in Chemistry 2020", The Royal Swedish Academy of Sciences, NobelPrize.org, 7 October 2020

image: Bianca Fioretti / Wikimedia Commons

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"It's CRISPR!" This week, the Nobel Prize in Chemistry was awarded to scientists Emmanuelle Charpentier and Jennifer Doudna (also an a16z co-founder, of Scribe Therapeutics), for the development of the CRISPR/Cas9 method for genome editing -- a technology that's "had a revolutionary impact on the life sciences, is contributing to new cancer therapies, and may make the dream of curing inherited diseases come true".

While many describe this technology as "genetic scissors", one of the sharpest tools, is that analogy too limited for describing the true power and potential of CRISPR as a gene-editing platform? And while the time between (unexpected) discovery to practice to award has been less than a decade -- further confirming that we're in the new century of biology! -- at what point does such discovery become engineering, that is, innovations we can use and systematize and scale (much like transistors)?

In this special episode of 16 Minutes, a16z general partners Vijay Pande and Jorge Conde, in conversation with Sonal Chokshi, examine the long arc and narrative of CRISPR, both backwards and forward; tease apart what's hype/ what's real in terms of where we really are, in practice; and... celebrate the incredible milestone this is. It's CRISPR!, and much more...

articles cited in this episode [see also related pieces below]

"Pioneers of revolutionary CRISPR gene editing win chemistry Nobel", Heidi Ledford & Ewen Callaway, Nature, 7 October 2020

"The Nobel Prize in Chemistry 2020", The Royal Swedish Academy of Sciences, NobelPrize.org, 7 October 2020

image: Bianca Fioretti / Wikimedia Commons

Previous Episode

undefined - Nvidia + Arm

Nvidia + Arm

We cover the latest news since Nvidia (maker of GPUs among other things) announced its intent to acquire Arm (provider of silicon IP for system-on-chips inside billions of devices), arguing that "This combination has tremendous benefits for both companies, our customers, and the industry." But how so, when critics are worried about channel conflict, shepherding the broader ecosystem of users, and other issues? Some believe the deal may not go through, and there are also concerns about it for geopolitical reasons (U.S.-based Nvidia, UK-based Arm, China), so how do we tease apart "what's hype/ what's real" here when it comes to understanding the broader implications of the deal?

In this episode of our news analysis show, we go beyond the current headlines and focus on the deeper questions -- and longer history of computing innovation -- behind what a potential merger like this could mean for the industry. Given the various tech trends involved here -- from cloud-native and mobile-first to "ML inside", as well as computing going more and more to the edges -- where do and don't the (seemingly) inherent low-energy, low-cost advantages of the RISC architecture, or rather, Arm vs. Intel chip designs come in? Wherefore open source, could a consortium work? If value is always moving up the stack -- and the divisions between hardware, software, firmware, applications, etc. don't remain stable for a very long time -- who are the players that are really changing the game here... And what if it's the entire gameboard that's changed? Former Microsoft Windows president and a16z board partner Steven Sinofsky and a16z operating partner Frank Chen share their thoughts on all this and more with host Sonal Chokshi.

image: Adam Greig / Flickr

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is ...

Next Episode

undefined - Gaming Is Among Us

Gaming Is Among Us

Aliens are among us. Well, the online multiplayer game Among Us is -- a murder mystery set in space, where the group must figure out who the alien imposter is (a variation of party games like Werewolf or Mafia) -- has seemingly suddenly become very popular. And not just because a major politician livestream-played it earlier this week, which is what makes this news.

So on this episode of 16 Minutes on the News -- our show where we talk about what's in the headlines; tease apart what's hype/ what's real; and where we are on the long arc of innovation with related tech trends -- we cover:

  • Who, how, and why now? Especially since the game, from indie game company InnerSloth, has been around since 2018 -- what if it's NOT just "the pandemic effect" (where people are seeking new ways to connect);
  • What are the underlying trends involved -- from social to streaming -- but digging in on the twists, and nuances, of both;
  • What are the implications for startups and big companies when it comes to the gaming market, beyond this game?

All this and more, in less than 16 minutes, with a16z consumer team partner Jonathan Lai (formerly at Tencent games, Riot Games) in conversation with host Sonal Chokshi.

headlines & sources for stats/quotes cited in this episode:

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