搞乜咁科學 #33 - 一個人生B與叻過Chat GPT Making Baby DIY & Outsmarting AI 🍼

歡迎嚟到 搞乜咁科學 GMG Science 第33集!

今集嘅主題係《一個人生B與叻過ChatGPT Baby Making DIY & Human Outsmarting AI》🍼!Abellona講唔洗精子卵子都可以做到B? 🐣 Keith會講有咩你肯定叻過啲AI?!🤔

喂!好奇心,係時候醒喇 :)

Social Media:

科學一齊搞 Got Something for GMG - 有咩想同我哋講都可以係度share㗎: http://hello.gmgscience.com/

搞乜咁科學網頁: http://www.gmgscience.com

搞乜咁科學 IG: http://www.instagram.com/gmgscience

搞乜咁科學 YouTube: https://www.youtube.com/@gmgscience

Abellona IG: http://www.instagram.com/_doctor_u

Keith IG: http://www.instagram.com/keith.poonsir

Keith YouTube: http://www.youtube.com/@KeithPoonSir

後期製作 Ah Long IG: http://www.instagram.com/arlongphotog.hk

Show Notes and Links:

大部份今集有關嘅圖片會係我哋IG見到㗎: http://www.instagram.com/gmgscience

Abellona’s Part

體外人工受精 In vitro fertilisation - Wikipedia

改編自體外人工受精背後嘅故事嘅電影:Joy - Film

易入口d介紹體外人工製造卵子技術最新發展嘅文章:

Making Eggs Without Ovaries - Asimov Press

體外人工製造配子技術嘅科學雜誌總結:

Mitinori Saitou, Katsuhiko Hayashi ,Mammalian in vitro gametogenesis.Science374,eaaz6830(2021).DOI:10.1126/science.aaz6830

第一步:將幹細胞引導為初始生殖細胞,即係精子卵子嘅前驅細胞:

Hikabe, O., Hamazaki, N., Nagamatsu, G. et al. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature 539, 299–303 (2016). https://doi.org/10.1038/nature20104

第二步:使初始生殖細胞重寫佢DNA上面嘅tag (Epigenetic modification):

Murase, Y., Yokogawa, R., Yabuta, Y. et al. In vitro reconstitution of epigenetic reprogramming in the human germ line. Nature 631, 170–178 (2024). https://doi.org/10.1038/s41586-024-07526-6

第三步:有正確數量嘅染色體,分別係由兩個copy 變一個copy:

Aleksei Mikhalchenko et al. ,Induction of somatic cell haploidy by premature cell division. Sci. Adv. 10,eadk9001(2024).DOI:10.1126/sciadv.adk9001

同埋如果要將來自男性嘅細胞變成卵子,要由XY變成XX:

Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x

第四部:培殖發展為成熟嘅精子/卵子

Takashi Yoshino et al. ,Generation of ovarian follicles from mouse pluripotent stem cells.Science373,eabe0237(2021).DOI:10.1126/science.abe0237

嘗試發展呢嘅技術嘅生物技術初創,例如:https://conception.bio

Keith’s Part

Ned Block 講 AI - Robinson Erhardt on YouTube